{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:04:11Z","timestamp":1787015051010,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,12,20]],"date-time":"2006-12-20T00:00:00Z","timestamp":1166572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:p>\n                    <jats:bold>Background:\u2002<\/jats:bold>\n                    Mucous membrane pemphigoid is an autoimmune mucocutaneous blistering disease. A subset, known as anti\u2010epiligrin cicatricial pemphigoid is associated with a high risk for malignancy. Oral pemphigoid (OP) is limited to the oral cavity. The purpose of this study was to determine the association between malignancy and patients with OP with antibodies to\n                    <jats:italic>\u03b1<\/jats:italic>\n                    6\u2010integrin subunit.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:\u2002<\/jats:bold>\n                    We determined the incidence of cancer in 72 patients with OP and compared it to the expected incidence using age and sex\u2010specific rates of malignancy in the National Cancer Institute's Surveillance, Epidemiology, and End Results (NCI SEER) Registry.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:\u2002<\/jats:bold>\n                    During a mean observation period of 9.1\u2003years (range: 2.8\u201340), for 70, three OP patients developed malignancies. The expected number of cancers based on the NCI SEER Registry was 8.83. The relative risk for cancer in OP patients, with autoantibodies to\n                    <jats:italic>\u03b1<\/jats:italic>\n                    6\u2010integrin, was 0.34 (95% CI, 0.07\u20130.99,\n                    <jats:italic>P<\/jats:italic>\n                    \u2003&lt;\u20030.05).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:\u2002<\/jats:bold>\n                    It appears that patients with OP, with antibodies to\n                    <jats:italic>\u03b1<\/jats:italic>\n                    6, may have a possible reduced relative risk for developing cancer.\n                  <\/jats:p>","DOI":"10.1111\/j.1600-0714.2006.00483.x","type":"journal-article","created":{"date-parts":[[2010,8,18]],"date-time":"2010-08-18T08:32:58Z","timestamp":1282120378000},"page":"1-5","source":"Crossref","is-referenced-by-count":23,"title":["Relationship between cancer and oral pemphigoid patients with antibodies to \u03b16\u2010integrin"],"prefix":"10.1111","volume":"36","author":[{"given":"Mohsin","family":"Malik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakan M.","family":"G\u00fcrcan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Christen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Razzaque Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,12,20]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.107248"},{"key":"e_1_2_5_3_2","doi-asserted-by":"crossref","first-page":"189","DOI":"10.2340\/0001555554189192","article-title":"Demonstration of basement membrane autoantibodies in patients with benign mucous membrane pemphigoid","volume":"54","author":"Dabelsteen E","year":"1974","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/00220345010800080601"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04971-0"},{"key":"e_1_2_5_6_2","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S1016-8478(23)13027-5","article-title":"Contributions of the alpha6 integrins to breast carcinoma survival and progression","volume":"17","author":"Chung J","year":"2004","journal-title":"Mol Cells"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910630206"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00118187"},{"key":"e_1_2_5_9_2","first-page":"725","article-title":"alpha6 integrin expression in esophageal carcinoma","volume":"16","author":"Tanaka Y","year":"2000","journal-title":"Int J Oncol"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006659230585"},{"key":"e_1_2_5_11_2","first-page":"1","article-title":"High expression level of alpha 6 integrin in human breast carcinoma is correlated with reduced survival","volume":"55","author":"Friedrichs K","year":"1995","journal-title":"Cancer Res"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01438306"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1988.tb01747.x"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(98)90395-X"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2002.01942.x"},{"key":"e_1_2_5_16_2","volume-title":"About SEER","author":"National Cancer Institute","year":"2005"},{"key":"e_1_2_5_17_2","unstructured":"RosnerB. 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