{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T21:50:38Z","timestamp":1783979438137,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,3,27]],"date-time":"2007-03-27T00:00:00Z","timestamp":1174953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Recurrent oral aphthous ulceration (ROAU) is a common problem that can result in considerable pain and distress for patients. The aim of this pilot study was to evaluate the role of subantimicrobial dose doxycycline (SDD \u2013 20\u2003mg doxycycline twice daily) in the management of patients with ROAU.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> 50 patients with ROAU were randomly allocated to treatment with SDD or placebo for 90\u2003days. Daily ulcer diaries were completed by the participants to record the number of new ulcers and the pain associated with the ulcers.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> There were significantly more days with no new ulcers in the SDD group (80.4\u2003\u00b1\u20035.9) than the placebo group (69.8\u2003\u00b1\u200318.7; <jats:italic>P<\/jats:italic>\u2003=\u20030.04). Strong trends were observed towards fewer new ulcers per day, fewer new ulcers over the 90\u2010day period, and more days with no pain in the SDD group compared with the placebo group (<jats:italic>P<\/jats:italic>\u2003=\u20030.06\u20130.08).<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> SDD shows promise as potential therapy in the management of ROAU, though this needs to be confirmed in further studies.<\/jats:p>","DOI":"10.1111\/j.1600-0714.2007.00507.x","type":"journal-article","created":{"date-parts":[[2010,8,18]],"date-time":"2010-08-18T13:03:46Z","timestamp":1282136626000},"page":"236-240","source":"Crossref","is-referenced-by-count":34,"title":["Subantimicrobial dose doxycycline in the treatment of recurrent oral aphthous ulceration: a pilot study"],"prefix":"10.1111","volume":"36","author":[{"given":"Philip M.","family":"Preshaw","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Grainger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark H.","family":"Bradshaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdel R.","family":"Mohammad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris V.","family":"Powala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Nolan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,3,27]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"95","article-title":"Recurrent aphthous stomatitis","volume":"31","author":"Ship JA","year":"2000","journal-title":"Quintessence Int"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0007-117X(77)90006-3"},{"key":"e_1_2_5_4_2","first-page":"141","article-title":"Oral ulcerations","volume":"21","author":"Woods MA","year":"1990","journal-title":"Quintessence Int"},{"key":"e_1_2_5_5_2","volume-title":"Clinician's guide to the treatment of common oral conditions","author":"Siegel MA","year":"2006"},{"key":"e_1_2_5_6_2","first-page":"364","article-title":"Management of painful oral ulcers","volume":"9","author":"Jandinski JJ","year":"1988","journal-title":"Compendium"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/003693308903400509"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.4809326"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/58.1.41"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.4803212"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1994.tb00057.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1998.tb01927.x"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199908)29:08<2645::AID-IMMU2645>3.0.CO;2-1"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.54.7.590"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.18.11.1707"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1990.tb00923.x"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1995.tb00120.x"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s000110050193"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.4.521"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.8.1068"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00840.x"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.9.1465"},{"key":"e_1_2_5_23_2","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/sj.bdj.4812649","article-title":"Oral medicine \u2013 update for the dental practitioner. 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