{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:55:04Z","timestamp":1762865704746},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,2,13]],"date-time":"2007-02-13T00:00:00Z","timestamp":1171324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Oral lichen planus (OLP) is characterized among other features by apoptosis of basal keratinocytes. To identify potential regulatory mechanisms associated with basal cell apoptosis in OLP, we investigated the expression of CD40, CD40 ligand (CD40L), CD44 and epithelial (E)\u2010cadherin.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Biopsies from 22 patients with OLP were investigated by immunohistochemistry for detection of CD40, CD40L, E\u2010cadherin, CD44, Laminin\u20105 and Collagen IV, double\u2010labelling for CD40 and CD3, and <jats:italic>in situ<\/jats:italic> mRNA hybridization for CD40 and CD40L.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> In actively diseased areas of OLP lesions, basal keratinocytes did not express CD40 and were focally E\u2010cadherin\u2010negative, in contrast to non\u2010diseased areas and normal oral mucosa. Demonstration of intraepithelial T cells expressing CD40 and CD40L, indicates a potential role in inflammatory cell responses involved in the disease process of OLP.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> T cells may orchestrate inflammatory cell responses in OLP via CD40\u2013CD40L interactions. As basal keratinocytes downregulate CD40, they may escape CD40\u2013CD40L\u2010induced apoptosis in OLP. On the other hand, loss of E\u2010cadherin expression may contribute to epithelial basal cell destruction and T\u2010cell migration into the epithelial compartment in OLP.<\/jats:p>","DOI":"10.1111\/j.1600-0714.2007.00511.x","type":"journal-article","created":{"date-parts":[[2010,8,18]],"date-time":"2010-08-18T12:33:53Z","timestamp":1282134833000},"page":"153-160","source":"Crossref","is-referenced-by-count":20,"title":["Altered CD40 and E\u2010cadherin expression \u2013 putative role in oral lichen planus"],"prefix":"10.1111","volume":"36","author":[{"given":"E.","family":"Neppelberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. L.","family":"Loro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"\u00d8ijordsbakken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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