{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T23:46:30Z","timestamp":1773186390774,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,3,27]],"date-time":"2007-03-27T00:00:00Z","timestamp":1174953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Keratinocytes in oral lichen (OL) planus have been shown to be exposed to potentially cell death\u2010inducing factors such as tumour necrosis factor\u2010<jats:italic>\u03b1<\/jats:italic> (TNF\u2010<jats:italic>\u03b1<\/jats:italic>) and FasL, produced by the cells of the inflammatory infiltrate and by the keratinocytes themselves. Mostly, however, the lesions do not show ulceration, the clinical manifestation of substantial keratinocyte death. The aim of this study was to find support for the contention that there is activation of protecting anti\u2010apoptotic mechanisms in keratinocytes in a form of chronic OL (erythematous OL; ERY OL), simultaneously with the pathological cell death signals.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Biopsies from patients with normal oral mucosa (NOM) or with ERY OL were compared by immunohistological staining.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> In ERY OL keratinocytes, both the pro\u2010apoptotic FADD and the anti\u2010apoptotic molecules p\u2010IKK, NF\u2010<jats:italic>\u03ba<\/jats:italic>B\/p50, FLIP<jats:sub>L<\/jats:sub>, cIAP\u20101 and cIAP\u20102 were strongly upregulated when compared with NOM. There were no significant differences in the staining patterns for active caspase\u20103 and caspase\u20108 with only few positive cells for both enzymes.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> The presently observed marked increase in expression of anti\u2010apoptotic molecules in ERY OL epithelium may counteract the pro\u2010apoptotic assault and rescue the epithelium from rampant cell death and thereby clinical ulceration.<\/jats:p>","DOI":"10.1111\/j.1600-0714.2007.00519.x","type":"journal-article","created":{"date-parts":[[2010,8,18]],"date-time":"2010-08-18T13:09:35Z","timestamp":1282136975000},"page":"215-222","source":"Crossref","is-referenced-by-count":23,"title":["Survival signalling in keratinocytes of erythematous oral lichen planus"],"prefix":"10.1111","volume":"36","author":[{"given":"Andreas","family":"Karatsaidis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhiko","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olav","family":"Schreurs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristen","family":"Helgeland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl","family":"Schenck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,3,27]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1988.tb01527.x"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(91)90007-Y"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1986.tb00621.x"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(84)90184-1"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2005.00373.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1309\/GHY8AL2D45P2R234"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1601-0825.2003.00998.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2003.00077.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12606990"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0722.2001.00081.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2000.290802.x"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.21.16.5299-5305.2001"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5383.1680"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401722"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2003.00134.x"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0904-2512.2004.00064.x"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.10.001"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00521-X"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C000792200"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80252-6"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80984-8"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.02579"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M101780200"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/40657"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.01.041"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700020"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2004.12.003"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-005-4293-6"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M203484200"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0431215100"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/16.23.6914"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.8.2215"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(01)01844-8"},{"key":"e_1_2_5_35_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.17.11549"},{"key":"e_1_2_5_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81589-5"},{"key":"e_1_2_5_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/35085008"},{"key":"e_1_2_5_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1630"}],"container-title":["Journal of Oral Pathology &amp; 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