{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:03:21Z","timestamp":1787015001124,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2007,5,21]],"date-time":"2007-05-21T00:00:00Z","timestamp":1179705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:p>\n                    <jats:bold>Background:\u2002<\/jats:bold>\n                    Squamous cell carcinoma of the oral cavity is a highly invasive neoplasm that spreads locally and metastasizes to regional lymph nodes. This process involves multiple proteolytic enzymes including matrilysin (MMP\u20107) and membrane type I\u2010matrix metalloproteinase (MT1\u2010MMP). This study was designed to explore the association between MMP\u20107 and MT1\u2010MMP in the invasiveness and prognosis of oral squamous cell carcinoma (OSCC).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:\u2002<\/jats:bold>\n                    About 4\u2010\n                    <jats:italic>\u03bc<\/jats:italic>\n                    M, formalin\u2010fixed, paraffin\u2010embedded tissue sections from 69 patients with OSCC were immunohistochemically studied using specific antibodies against MMP\u20107 and MT1\u2010MMP proteins. Immunostaining was semiquantitatively scored, and results were correlated with histologic and clinical variables including clinical behavior and survival.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:\u2002<\/jats:bold>\n                    MMP\u20107 was observed only in cancer cells, and MT1\u2010MMP in both tumoral tissue and stroma. MMP\u20107 expression was significantly correlated with lymph node metastasis (\n                    <jats:italic>P<\/jats:italic>\n                    \u2003=\u20030.03; RR\u2003=\u20033.2). MT1\u2010MMP showed a significant association with TIMP\u20102 (in N+ cases) and p53 expression (\n                    <jats:italic>P<\/jats:italic>\n                    \u2003=\u20030.01). MMP\u20107 and MT1\u2010MMP displayed a survival relevance, and in multivariate analysis they were independent prognostic indicators, particularly in neck node\u2010positive cases.\n                  <\/jats:p>","DOI":"10.1111\/j.1600-0714.2007.00546.x","type":"journal-article","created":{"date-parts":[[2010,8,18]],"date-time":"2010-08-18T09:05:54Z","timestamp":1282122354000},"page":"415-424","source":"Crossref","is-referenced-by-count":54,"title":["Expression of MMP\u20107 and MT1\u2010MMP in oral squamous cell carcinoma as predictive indicator for tumor invasion and prognosis"],"prefix":"10.1111","volume":"36","author":[{"given":"J.\u2010C.","family":"De Vicente","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Lequerica\u2010Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Santamar\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.\u2010F.","family":"Fresno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,5,21]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1987.01860070076020"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-1157-03"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/1357-2725(95)00121-2"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1994.2503"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.114.1.111"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0625.2003.120201.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-1916"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)68680-6"},{"key":"e_1_2_6_10_2","doi-asserted-by":"crossref","first-page":"17213","DOI":"10.1016\/S0021-9258(18)71480-4","article-title":"SV40\u2010transformed 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