{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T22:49:23Z","timestamp":1788648563380,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2007,5,26]],"date-time":"2007-05-26T00:00:00Z","timestamp":1180137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Circulating matrix metalloproteinase\u20109 (MMP\u20109) is a prognostic factor for gastric cancer and vascular diseases, and has been associated with head and neck cancers. The <jats:bold>\u2212<\/jats:bold>1562 C\u2010to\u2010T polymorphism in <jats:italic>MMP\u20109<\/jats:italic> promoter (abbreviated <jats:italic>MMP\u20109<\/jats:italic><jats:bold>\u2212<\/jats:bold>1562 C&gt;T polymorphism) leads to differential transcription, and is associated with increased susceptibility to neoplastic and vascular diseases. Thus, our aim was to determine whether a functional <jats:italic>MMP\u20109<\/jats:italic> polymorphism might also influence the risk or affect the progression of areca\u2010associated oral cancers.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Genomic DNAs were obtained from peripheral blood cells of male subjects with areca\u2010associated oral squamous cell carcinoma (OSCC) (<jats:italic>n<\/jats:italic>\u2003=\u2003192), oral submucosal fibrosis (OSF) (<jats:italic>n<\/jats:italic>\u2003=\u200373), and non\u2010diseased areca users (<jats:italic>n<\/jats:italic>\u2003=\u2003191). The PCR\u2010based restriction fragment length polymorphism analysis was performed for <jats:italic>MMP\u2010<\/jats:italic>9 genotyping.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold>  <jats:italic>MMP\u20109<\/jats:italic>\n          <jats:bold>\u2212<\/jats:bold>1562 C&gt;T polymorphism was not associated with the risk of OSCC or OSF. However, when subjects were stratified by the median age, an association with the risk of OSCC was found in younger patients (<jats:italic>P\u2003=\u2003<\/jats:italic>0.029). The T allele frequency was significantly higher in the subset of older patients with buccal mucosa OSCC than older patients with OSCC in counterpart locations. The joint <jats:italic>MMP\u20109<\/jats:italic><jats:bold>\u2212<\/jats:bold>1562 C&gt;T and <jats:italic>MMP\u20103<\/jats:italic><jats:bold>\u2212<\/jats:bold>1171 5A&gt;6A functional polymorphisms were not associated with OSCC risk or patient survival.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Aberrant <jats:italic>MMP\u20109<\/jats:italic> expression is closely related to tumor invasiveness and the prognosis of head and neck cancers. However, functional <jats:italic>MMP\u20109<\/jats:italic><jats:bold>\u2212<\/jats:bold>1562 C&gt;T polymorphism is associated with OSCC risk only in younger areca chewers. The impact of aging or areca\u2010related effect on this functional polymorphism should be elucidated.<\/jats:p>","DOI":"10.1111\/j.1600-0714.2007.00552.x","type":"journal-article","created":{"date-parts":[[2010,8,18]],"date-time":"2010-08-18T12:39:08Z","timestamp":1282135148000},"page":"409-414","source":"Crossref","is-referenced-by-count":41,"title":["Functional \u22121562 C\u2010to\u2010T polymorphism in <i>matrix metalloproteinase\u20109<\/i> (<i>MMP\u20109<\/i>) promoter is associated with the risk for oral squamous cell carcinoma in younger male areca 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