{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T10:32:20Z","timestamp":1789813940310,"version":"4.0.1"},"reference-count":45,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2007,6,5]],"date-time":"2007-06-05T00:00:00Z","timestamp":1181001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:p>Oral lichen planus (OLP) is a chronic inflammatory oral mucosal disease. There are some studies in the literature demonstrating association between cytokines genes polymorphisms and susceptibility to develop some immune\u2010mediate conditions. The purpose of this study was to investigate cytokine gene polymorphisms in a sample of Brazilian patients with OLP. Fifty\u2010three patients with OLP (mean age\u2003=\u200343.1\u2003years; range 20\u201368\u2003years) and 53 healthy volunteers (mean age\u2003=\u200342.9\u2003years; range 21\u201367) were genotyped for <jats:italic>IL\u20101<\/jats:italic>\u03b2 +3954 (C\/T), <jats:italic>IL\u20106<\/jats:italic>\u2212174 (G\/C), <jats:italic>IL\u201010<\/jats:italic>\u22121082 (G\/A) and <jats:italic>TNFA<\/jats:italic>\u2212308 (G\/A) gene polymorphisms. Statistical analysis was based on the use of logistic regression (<jats:italic>P<\/jats:italic>\u2010values below 0.05 were considered as significant). <jats:italic>IL\u20106<\/jats:italic> and <jats:italic>TNFA<\/jats:italic> homozygous genotypes were significantly more often detected in OLP patients. These genotypes were associated with an increased risk of OLP development (OR 6.89 and 13.04, respectively). <jats:italic>IL\u20101<\/jats:italic>\u03b2 and <jats:italic>IL\u201010<\/jats:italic> gene polymorphisms were not related to OLP development. Our findings clearly demonstrate an association between inheritance of <jats:italic>IL\u20106<\/jats:italic> and <jats:italic>TNFA<\/jats:italic> gene polymorphisms and OLP occurrence, thus giving additional support for genetic basis of this disease.<\/jats:p>","DOI":"10.1111\/j.1600-0714.2007.00560.x","type":"journal-article","created":{"date-parts":[[2010,8,18]],"date-time":"2010-08-18T13:06:39Z","timestamp":1282136799000},"page":"476-481","source":"Crossref","is-referenced-by-count":47,"title":["Investigation of functional gene polymorphisms interleukin\u20101\u03b2, interleukin\u20106, interleukin\u201010 and tumor necrosis factor in individuals with oral lichen planus"],"prefix":"10.1111","volume":"36","author":[{"given":"Guilherme Machado","family":"Xavier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra Rosa 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