{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T06:14:37Z","timestamp":1759990477442},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2007,6,10]],"date-time":"2007-06-10T00:00:00Z","timestamp":1181433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Oral <jats:italic>Candida<\/jats:italic> spp., and <jats:italic>C. albicans<\/jats:italic> in particular, are considered as important aetiological agents in the pathogenesis of denture\u2010induced stomatitis. Several studies have reported that <jats:italic>C. albicans<\/jats:italic> is able to easily adhere to different medical devices, such as vascular and urinary catheters or acrylic denture surfaces, and that adhesion is a fundamental step in the initial pathogenic process of colonization and further possible infection. Recently, a synthetic decapeptide (KP) derived from the sequence of a single\u2010chain recombinant anti\u2010idiotypic antibody, acting as a functional internal image of a microbicidal, broad spectrum yeast killer toxin, has been reported to kill <jats:italic>in vitro C. albicans<\/jats:italic> cells and to exert a therapeutic activity against experimental mucosal and systemic candidiasis.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> The aim of this study was to evaluate, through a CFU assay, the candidacidal activity of KP on sanded acrylic resin discs, previously colonized by <jats:italic>C. albicans<\/jats:italic> cells.<\/jats:p><jats:p><jats:bold>Results and conclusions:<\/jats:bold>  At 100\u2003\u03bcg\/ml KP showed over 90% of killing activity on <jats:italic>C. albicans<\/jats:italic> cells adhered to resin discs, when compared with a scramble peptide used as control. The results of this study suggest a potential effect of KP on <jats:italic>C. albicans<\/jats:italic> cells adhered on the surface of resin materials, such as prosthetic dentures.<\/jats:p>","DOI":"10.1111\/j.1600-0714.2007.00561.x","type":"journal-article","created":{"date-parts":[[2010,8,18]],"date-time":"2010-08-18T13:14:04Z","timestamp":1282137244000},"page":"468-471","source":"Crossref","is-referenced-by-count":8,"title":["<i>In vitro<\/i> candidacidal activity of a synthetic killer decapeptide (KP) against <i>Candida albicans<\/i> cells adhered to resin acrylic discs"],"prefix":"10.1111","volume":"36","author":[{"given":"M.","family":"Manfredi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Merigo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Salati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Conti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Savi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Polonelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Bonanini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Vescovi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,6,10]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"156","volume-title":"Oral candidosis","author":"Budtz\u2010Jorgensen E","year":"1990"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-5712(97)00034-1"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(01)02094-7"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1354-523X.2003.00969.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2002.126024"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-146-9-2105"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3913(97)70148-3"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt0297-155"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.11.6205-6212.2003"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.2005.00217.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9969(98)00075-2"},{"key":"e_1_2_5_13_2","doi-asserted-by":"crossref","first-page":"3876","DOI":"10.1128\/iai.57.12.3876-3881.1989","article-title":"Environmental alteration and phenotypic regulation of Candida albicans adhesion to plastic","volume":"57","author":"Kennedy MJ","year":"1989","journal-title":"Infect Immun"},{"key":"e_1_2_5_14_2","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1128\/iai.50.1.97-101.1985","article-title":"Factors governing adherence of Candida species to plastic surfaces","volume":"50","author":"Klotz SA","year":"1985","journal-title":"Infect Immun"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.2005.00213.x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2004.00413.x"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/8.1.73"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl051"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2006.01.002"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkh430"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000222068.14878.0d"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(02)00002-1"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1080\/13693780500107554"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2003.04.002"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0714.2007.00561.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0714.2007.00561.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T20:33:43Z","timestamp":1696970023000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0714.2007.00561.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6,10]]},"references-count":23,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2007,9]]}},"alternative-id":["10.1111\/j.1600-0714.2007.00561.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0714.2007.00561.x","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,6,10]]}}}