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The tumor was typical, moderately well\u2010differentiated SCC but had many melanocytes (melanocytosis) within it. Immunohistochemical analysis for stem cell factor (SCF) and endothelin\u20101, both of which are known to stimulate proliferation and differentiation of melanocytes, revealed prominent expression of both factors in the neoplastic squamous cells of the pigmented SCC, while the non\u2010pigmented oral SCC showed little sign of either factor. These findings strongly suggest that SCF and endothelin\u20101 secreted by neoplasmic squamous cells are involved in the emergence of a rare variant of oral SCC.<\/jats:p>","DOI":"10.1111\/j.1600-0714.2007.00587.x","type":"journal-article","created":{"date-parts":[[2010,8,18]],"date-time":"2010-08-18T12:41:27Z","timestamp":1282135287000},"page":"621-624","source":"Crossref","is-referenced-by-count":15,"title":["Possible involvement of stem cell factor and endothelin\u20101 in the emergence of pigmented squamous cell carcinoma in oral mucosa"],"prefix":"10.1111","volume":"36","author":[{"given":"Kazuhito","family":"Satomura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reiko","family":"Tokuyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhumi","family":"Yamasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Yuasa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiko","family":"Tatehara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naozumi","family":"Ishimaru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshio","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaru","family":"Nagayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,7,12]]},"reference":[{"key":"e_1_2_3_2_2","first-page":"480","volume-title":"Comprehensive management of head and neck tumors","author":"Batsakis JG","year":"1987"},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1977.tb01641.x"},{"key":"e_1_2_3_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.02934.x"},{"key":"e_1_2_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9785(74)80011-6"},{"key":"e_1_2_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(81)90365-0"},{"key":"e_1_2_3_7_2","doi-asserted-by":"publisher","DOI":"10.2334\/josnusd1959.23.1"},{"key":"e_1_2_3_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1990.tb00775.x"},{"key":"e_1_2_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-4220(06)80108-8"},{"key":"e_1_2_3_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19970801)80:3<351::AID-CNCR1>3.0.CO;2-V"},{"key":"e_1_2_3_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0906-6705.2005.00320.x"},{"key":"e_1_2_3_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2004.00198.x"},{"key":"e_1_2_3_13_2","doi-asserted-by":"crossref","first-page":"24675","DOI":"10.1016\/S0021-9258(18)35817-4","article-title":"Endothelins secreted from human keratinocytes are intrinsic mitogens for human melanocytes","volume":"267","author":"Imokawa G","year":"1992","journal-title":"J Biol Chem"},{"key":"e_1_2_3_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041590204"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0714.2007.00587.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0714.2007.00587.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T08:21:02Z","timestamp":1697358062000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0714.2007.00587.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7,12]]},"references-count":13,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2007,11]]}},"alternative-id":["10.1111\/j.1600-0714.2007.00587.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0714.2007.00587.x","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,7,12]]}}}