{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T02:44:28Z","timestamp":1776912268498,"version":"3.51.2"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,8,4]],"date-time":"2007-08-04T00:00:00Z","timestamp":1186185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:p>To explore circulation levels of osteopontin (OPN), tumour necrosis factor (TNF)\u2010\u03b1 and transforming growth factor (TGF)\u2010\u03b21 from patients with oral lichen planus (OLP) for clinical application. A group of 26 subjects with OLP were compared with 26 sex\u2010 and age\u2010matched control (NC) subjects. Local lesion tissue was examined for OPN by immunohistochemical analysis. And, serum OPN, proinflammatory TNF\u2010\u03b1 and TGF\u2010\u03b21 levels were measured by enzyme\u2010linked immunoabsorbent assay. The serum concentrations of OPN and TNF\u2010\u03b1 were significantly higher in OLP patients than the NC group (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). Although serum concentrations of TGF\u2010\u03b21 increased slightly, they were not statistically significant. Erosive\u2010form OLP exhibited significantly elevated TGF\u2010\u03b21 serum levels, compared with reticular\u2010form OLP. The above results suggest that the production of OPN is associated with the inflammatory process of OLP development, and may serve as a potential disease marker of OLP.<\/jats:p>","DOI":"10.1111\/j.1600-0714.2007.00599.x","type":"journal-article","created":{"date-parts":[[2010,8,12]],"date-time":"2010-08-12T11:40:08Z","timestamp":1281613208000},"page":"94-98","source":"Crossref","is-referenced-by-count":20,"title":["Osteopontin expression in oral lichen planus"],"prefix":"10.1111","volume":"37","author":[{"given":"Zeng\u2010Tong","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben\u2010Juan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,8,4]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2003.00077.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0278-2391(92)90354-3"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5454.860"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(00)01715-1"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.271.5248.509"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M103608200"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4644(1998)72:30\/31 <92::AID-JCB13>3.0.CO;2-A"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI12980"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2613.2000.00163.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.41.1.723"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.2007.tb03884.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1062960"},{"key":"e_1_2_6_14_2","first-page":"1492","article-title":"Autoantibodies to osteopontin in patients with osteoarthritis and rheumatoid arthritis","volume":"28","author":"Sakata M","year":"2001","journal-title":"J Rheumatol"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1748"},{"key":"e_1_2_6_16_2","doi-asserted-by":"crossref","first-page":"191","DOI":"10.2340\/0001555577191193","article-title":"In situ expression and serum levels of tumor necrosis factor alpha receptors in patients with lichen planus","volume":"77","author":"Miklos S","year":"1997","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2004.00221.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200523273"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-2361"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1177\/154411130201300405"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.68.4.495"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200109)44:9<2097::AID-ART360>3.0.CO;2-6"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1995.tb44660.x"},{"key":"e_1_2_6_24_2","first-page":"2061","article-title":"Enhanced local production of osteopontin in rheumatoid joints","volume":"29","author":"Ohshima S","year":"2002","journal-title":"J Rheumatol"},{"key":"e_1_2_6_25_2","doi-asserted-by":"crossref","first-page":"3205","DOI":"10.4049\/jimmunol.155.6.3205","article-title":"SLE\u2010like autoantibodies and Sj\u00f6gren\u2019s syndrome\u2010like lymphoproliferation in TGF\u2010beta knockout mice","volume":"155","author":"Dang H","year":"1995","journal-title":"J Immunol"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/359693a0"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.5.1280"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(97)01000-1"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.108.2.661"}],"container-title":["Journal of Oral Pathology &amp; 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