{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:03:19Z","timestamp":1787014999708,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,9,4]],"date-time":"2007-09-04T00:00:00Z","timestamp":1188864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:p>\n                    <jats:bold>Background:\u2002<\/jats:bold>\n                    Recent reports of osteonecrosis of the jaw (ONJ) after dental surgery in patients treated with second\u2010 and third\u2010generation nitrogen\u2010containing bisphosphonates instigated this retrospective study. As treatment with bisphosphonates in patients with osteogenesis imperfecta (OI) has become an important symptomatic therapy, especially for severe forms of the disease, we found it important to investigate whether healing after surgical exposure of jaw bone was influenced by the bisphosponate treatment in our group of children, adolescents and young adults with OI.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Subjects and methods:\u2002<\/jats:bold>\n                    Disodiumpamidronate was given as monthly intravenous infusion to 64 patients with OI aged 3\u2003months to 20.9\u2003years at the start of treatment (mean 8.1, median 7.7). During 0.5\u201312.5\u2003years of treatment (mean 4.5, median 4.0), a total individual dose of 140\u20134020\u2003mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    disodiumpamidronate was given (mean 1623 and median 1460). Ten patients continued with oral alendronate and two with zoledronic acid therapy. In 22 of these patients, 38 dental surgery procedures were performed at the age of 3.4\u201331.9\u2003years (mean 12.2, median 12.3) after 0.03\u20137.9\u2003years of treatment (mean 3.6, median 3.4).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:\u2002<\/jats:bold>\n                    Despite long\u2010term intravenous monthly disodiumpamidronate treatment, none of the 64 patients had any clinical signs of ONJ.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:\u2002<\/jats:bold>\n                    The risk of ONJ in these patients must be considered so low that the patients with indications for treatment should be treated and get the chance to experience the well\u2010documented beneficial effect for children with severe OI.\n                  <\/jats:p>","DOI":"10.1111\/j.1600-0714.2007.00607.x","type":"journal-article","created":{"date-parts":[[2010,8,12]],"date-time":"2010-08-12T07:39:53Z","timestamp":1281598793000},"page":"196-200","source":"Crossref","is-referenced-by-count":78,"title":["No osteonecrosis in jaws of young patients with osteogenesis imperfecta treated with bisphosphonates"],"prefix":"10.1111","volume":"37","author":[{"given":"Barbro","family":"Malmgren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"\u00c5str\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"S\u00f6derh\u00e4ll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,9,4]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1998.tb01388.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199810013391402"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021371"},{"key":"e_1_2_6_5_2","first-page":"27","article-title":"Two modes of action of bisphosphonates on osteoclastic resorption of mineralized matrix","volume":"1","author":"Boonekamp PM","year":"1986","journal-title":"Bone Miner"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/000992289903801201"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2003.036590"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(03)00720-1"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2005.07.010"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2004.02.004"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(03)00328-8"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21130"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2005.tb06970.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2005.tb06762.x"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-144-10-200605160-00009"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2005.08.001"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2004.00269.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00842.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.2005.tb00384.x"},{"key":"e_1_2_6_20_2","first-page":"58","article-title":"Diphosphonates can cause necrosis of the jaw. Patients with malignant skeletal diseases are at risk","volume":"98","author":"Jarnbring F","year":"2006","journal-title":"Tandlakartidningen"},{"key":"e_1_2_6_21_2","first-page":"972","article-title":"Bisphosphonate\u2010induced osteonecrosis: a new phenomenon","volume":"110","author":"Diernaes M","year":"2006","journal-title":"Tandlaegebladet"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.86.5.356"},{"key":"e_1_2_6_23_2","unstructured":"ChangJ.ODS postmarketing safety rev. ODS PID D040283 bisphosphonates osteonecrosis and osteomyelitis 2004. 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