{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T05:58:52Z","timestamp":1767851932171,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,9,4]],"date-time":"2007-09-04T00:00:00Z","timestamp":1188864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Odontogenic neoplasms have some morphologic overlap with salivary gland neoplasms, many of which show myoepithelial differentiation. In the 1980s, an ultrastructural study identified a population of myoepithelial\u2010like cells in calcifying epithelial odontogenic tumor. Myoepithelial derived tumors have since been shown to have distinct immunohistochemical profiles.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> We examined a series of odontogenic neoplasms, including 11 ameloblastomas, four calcifying epithelial odontogenic tumors, five glandular odontogenic cysts (GOCs), and five keratocystic odontogenic tumors with a panel of myoepithelial\u2010associated immunohistochemical stains. We also assessed representative control examples of oral mucosa, odontogenic rests, and dentigerous cysts.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> All of the neoplastic and non\u2010neoplastic oral epithelium\u2010derived entities share a p63\u2010positive, high molecular weight cytokeratin (CK5\/6)\u2010positive immunophenotype. Calponin reactivity was at least focally present in two of four calcifying epithelial odontogenic tumors, three of five GOCs, and 10 of 11 ameloblastomas; the sole completely non\u2010reactive ameloblastoma represents a lung metastasis. One case of calcifying epithelial odontogenic tumor was focally positive for glial fibrillary acidic protein. However, other more definitive markers of myoepithelial differentiation, including S\u2010100 and smooth muscle actin, were negative. Two of three calcifying epithelial odontogenic tumors and five of five GOCs were also positive for a low molecular weight cytokeratin (CK7).<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Ameloblastomas, GOCs, and calcifying epithelial odontogenic tumors show a distinctive immunophenotype which overlaps with that of myoepithelial\u2010derived salivary gland neoplasms but does not provide definitive support for myoepithelial differentiation.<\/jats:p>","DOI":"10.1111\/j.1600-0714.2007.00613.x","type":"journal-article","created":{"date-parts":[[2010,8,12]],"date-time":"2010-08-12T11:38:19Z","timestamp":1281613099000},"page":"177-184","source":"Crossref","is-referenced-by-count":40,"title":["Ameloblastoma, calcifying epithelial odontogenic tumor, and glandular odontogenic cyst show a distinctive immunophenotype with some myoepithelial antigen expression"],"prefix":"10.1111","volume":"37","author":[{"given":"Dita","family":"Gratzinger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed E.","family":"Salama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine F.","family":"Poh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert V.","family":"Rouse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,2,3]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"241","volume-title":"Oral pathology","author":"Regezi JA","year":"2003"},{"key":"e_1_2_5_3_2","volume-title":"Tumors and cysts of the jaw","author":"Sciubba JJ","year":"2001"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(99)00061-5"},{"key":"e_1_2_5_5_2","first-page":"1093","article-title":"Immunolocalization of three novel smooth muscle\u2010specific proteins in salivary gland pleomorphic adenoma: assessment of the morphogenetic role of myoepithelium","volume":"10","author":"Savera AT","year":"1997","journal-title":"Mod Pathol"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.5858\/1999-123-0801-TMIIBA"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2004.08.007"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1984.tb02380.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/106689690501300108"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004280050170"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2003.00063.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0722.2000.00717.x"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-0825.2003.00861.x"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2003.11.007"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1989.tb00738.x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2005.00352.x"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2005.00284.x"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2004.12.002"},{"key":"e_1_2_5_19_2","first-page":"414","volume-title":"Histology for pathologists","author":"Martinez\u2010Madrigal F","year":"1997"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-003-0859-2"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200108000-00010"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880483"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1177\/002215540305100201"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1309\/21TW-2NDG-JRK4-PFJX"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2006.02408.x"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-198812040-00008"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2004.01891.x"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200309000-00001"},{"key":"e_1_2_5_29_2","first-page":"130A","article-title":"Comparative analysis of the purported immunohistochemical \u201cmyoepithelial markers\u201d","volume":"12","author":"Savera AT","year":"1999","journal-title":"Mod Pathol"},{"key":"e_1_2_5_30_2","first-page":"619","article-title":"S\u2010100 protein antibodies do not label normal salivary gland myoepithelium. 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