{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T23:48:45Z","timestamp":1788392925107,"version":"build-2803163510"},"reference-count":9,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2008,4,11]],"date-time":"2008-04-11T00:00:00Z","timestamp":1207872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Although the effect of betel quid chewing and smoking on oral cancer has been well documented, both influences, dose and duration during life time, on multistate progression of oral pre\u2010malignancy are hardly addressed.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> By recruiting a group of male chewers from different occupation groups, we modeled the effects of both duration and quantity of betel quid chewing and smoking on annual incidence rate of developing leukoplakia and average dwelling times (ADTs) staying in leukoplakia and erythroleukoplakia.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The annual incidence rate (per year) of leukoplakia was estimated as 0.35% (95% CI: 0.22\u20130.48%). The ADTs were 24\u2003years for leukoplakia and 7\u2003years for erythroleukoplakia. Annual incidence rate of leukoplakia with high consumption and long duration of betel quid and smoking was higher. Both quantity and duration of smoking and betel quid chewing play minor roles in the influence of ADT. The risks of developing oral cancer after 20\u2003years of follow\u2010up were 42.2% for leukoplakia and 95.0% for erythroleukoplakia.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> The effects of betel quid chewing and smoking on multistate progressions between oral pre\u2010malignancies were elucidated. These results can be applied to predict long\u2010term risk of malignant transformation varying with different duration and quantity of betel quid and cigarette.<\/jats:p>","DOI":"10.1111\/j.1600-0714.2008.00652.x","type":"journal-article","created":{"date-parts":[[2010,8,12]],"date-time":"2010-08-12T11:51:40Z","timestamp":1281613900000},"page":"417-422","source":"Crossref","is-referenced-by-count":41,"title":["The effect of betel quid and cigarette on multistate progression of oral pre\u2010malignancy"],"prefix":"10.1111","volume":"37","author":[{"given":"Amy Ming\u2010Fang","family":"Yen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao\u2010Ching","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu\u2010Hui","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony Hsiu\u2010Hsi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,7,9]]},"reference":[{"key":"e_1_2_5_2_2","volume-title":"Monographs on the evaluation of carcinogenic risks to humans","author":"IARC","year":"2004"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008469-200402000-00007"},{"key":"e_1_2_5_4_2","first-page":"133","article-title":"Oral leukoplakia\u2014rationale for diagnosis and prognosis of its clinical subtypes or \u2018phases\u2019","volume":"25","author":"Bouquot JE","year":"1994","journal-title":"Quintessence Int"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2006.05.001"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780141404"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0006-341X.2000.00167.x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19840201)53:3<563::AID-CNCR2820530332>3.0.CO;2-F"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0842"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600727"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0714.2008.00652.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0714.2008.00652.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T14:48:13Z","timestamp":1697035693000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0714.2008.00652.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7,9]]},"references-count":9,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["10.1111\/j.1600-0714.2008.00652.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0714.2008.00652.x","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,7,9]]}}}