{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T14:05:33Z","timestamp":1768399533565,"version":"3.49.0"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,1,2]],"date-time":"2009-01-02T00:00:00Z","timestamp":1230854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2009,4]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> The purpose of this study was to determine prognostic factors for the recurrence of keratocystic odontogenic tumors (KCOTs) following simple enucleation by examining clinico\u2010pathologic and immunohistochemical findings.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Following enucleation, the frequency of recurrence among 32 subjects diagnosed with KCOT was analyzed for tumor site, radiographic and histologic features, and immunopositivity for Ki\u201067 and p53.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Keratocystic odontogenic tumors in four out of 32 subjects (12.5%) recurred during the follow\u2010up period (median: 33\u2003months, range: 7\u2013114\u2003months). Three out of four subjects (75.0%) among recurrent group showed high expression of Ki\u201067 (LI &gt;10%) in basal layer and four (4\/28; 14.3%) among non\u2010recurrence group (<jats:italic>P<\/jats:italic>\u2003=\u20030.025). Expression of p53 among non\u2010recurrent group was observed in 11 subjects (11\/28; 39.3%), and in three subjects (3\/4; 75.0%) among the recurrent group (<jats:italic>P<\/jats:italic>\u2003=\u20030.295). Hazard risk for the recurrence of KCOT was 4.02 (95% CI 1.42\u201318.14) for high Ki\u201067 expression in the basal layer by the Cox proportional hazard model (<jats:italic>P<\/jats:italic>\u2003<jats:italic>=<\/jats:italic>\u20030.009). In our study, none of the other clinico\u2010pathologic variables were associated with the recurrence of KCOT.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> The results suggested that the evaluation of Ki\u201067 expression in KCOT at the time of pathological diagnosis might be helpful for consideration of appropriate adjunctive surgical procedures to avoid a recurrence and may serve as a prognostic marker.<\/jats:p>","DOI":"10.1111\/j.1600-0714.2008.00729.x","type":"journal-article","created":{"date-parts":[[2010,8,12]],"date-time":"2010-08-12T11:35:12Z","timestamp":1281612912000},"page":"386-392","source":"Crossref","is-referenced-by-count":73,"title":["Prognostic factors for keratocystic odontogenic tumor (odontogenic keratocyst): analysis of clinico\u2010pathologic and immunohistochemical findings in cysts treated by enucleation"],"prefix":"10.1111","volume":"38","author":[{"given":"Norio","family":"Kuroyanagi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidenori","family":"Sakuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Miyabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junichiro","family":"Machida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuo","family":"Kaetsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoo","family":"Yokoi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hatsuhiko","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saman","family":"Warnakulasuriya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Nagao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Shimozato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,3,20]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(76)90031-1"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0278-2391(84)90390-2"},{"key":"e_1_2_7_4_2","first-page":"306","volume-title":"World Health Organization classification of tumours: pathology and genetic of head and neck tumours","author":"Philipsen HP","year":"2005"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2006.10.011"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2006.00455.x"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0266-4356(87)90065-9"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(01)00065-3"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2000.110814"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(01)00066-5"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2006.00382.x"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2004.04.017"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2001.113109"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(96)80418-5"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1995.tb01171.x"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.133.4.1710"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1996.tb01307.x"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0901-5027(88)80224-8"},{"key":"e_1_2_7_19_2","doi-asserted-by":"crossref","first-page":"313","DOI":"10.5858\/2004-128-313-MATDTO","article-title":"Molecular analysis to demonstrate that odontogenic keratocysts are neoplastic","volume":"128","author":"Agaram NP","year":"2004","journal-title":"Arch Pathol Lab Med"}],"container-title":["Journal of Oral Pathology &amp; 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