{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T12:02:07Z","timestamp":1720094527040},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,12,30]],"date-time":"2008-12-30T00:00:00Z","timestamp":1230595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> The maintenance mechanisms of peripheral tolerance by CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>+<\/jats:sup> T cells before the development of sialoadenitis in secondary Sj\u00f6gren\u2019s syndrome (sSS) are not well understood. The aim of the present study is to examine the effect of reduction of CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>+<\/jats:sup> T cells on the development of sialoadenitis during the early life in female NZB\u2003\u00d7\u2003NZWF<jats:sub>1<\/jats:sub> (B\/WF<jats:sub>1<\/jats:sub>) mice, a model for human sSS.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Female B\/WF<jats:sub>1<\/jats:sub> mice at 3\u2003days after birth were treated with either anti\u2010mouse CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>+<\/jats:sup> T cells rat IgG<jats:sub>1<\/jats:sub> monoclonal antibody (mAb) or Rat IgG<jats:sub>1<\/jats:sub>(control). At 25\u2003weeks of age, autoantibodies against nucleus and cytoplasm of ductal epithelial and myoepithelial cells, and histpathology of submandibular glands were examined in the mAb\u2010treated and control groups. Also the development of anti\u2010Ro\/SS\u2010A antibodies was examined until 25\u2003weeks of age in both groups.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The mAb\u2010treated group showed severe lesions with the development of autoantibodies compared to the control group.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> The present results suggest that peripheral CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>+<\/jats:sup> T cells may, at least in part, contribute to down\u2010regulate the development of sialoadenitis in submandibular glands of lupus\u2010prone female B\/WF<jats:sub>1<\/jats:sub> mice during their early life.<\/jats:p>","DOI":"10.1111\/j.1600-0714.2008.00730.x","type":"journal-article","created":{"date-parts":[[2010,8,12]],"date-time":"2010-08-12T12:04:07Z","timestamp":1281614647000},"page":"234-240","source":"Crossref","is-referenced-by-count":4,"title":["Systemic treatment of anti\u2010CD4<sup>+<\/sup>CD25<sup>+<\/sup> T cell monoclonal antibody exacerbates sialoadenitis in submandibular glands during the early life in lupus\u2010prone female NZB\u2003\u00d7\u2003NZWF<sub>1<\/sub> mice"],"prefix":"10.1111","volume":"38","author":[{"given":"Toshiharu","family":"Hayashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chie","family":"Adachi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiko","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,19]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:BGEN.0000038023.36727.50"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2004.12.002"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1191\/096120398678920046"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.2004.00183.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5312.604"},{"key":"e_1_2_5_7_2","first-page":"34","article-title":"Antibodies to Ro and La","volume":"149","author":"Reichlin M","year":"1998","journal-title":"Ann Med Interne"},{"key":"e_1_2_5_8_2","first-page":"1","article-title":"Circulating auto\u2010antibodies against nuclear and non\u2010nuclear antigens in primary Sj\u00f6gren\u2019s syndrome prevalence and clinical significance in 335 patients","volume":"25","author":"Nardi N","year":"2005","journal-title":"Clin Rheumatol"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1006\/clim.2002.5189"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-008-0627-4"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2004100837"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1191\/0961203303lu1002oa"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0300-9475.2004.01370.x"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0959-9673.2005.00438.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.12.5979"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1053\/jcpa.2001.0493"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1191\/0961203303lu483oa"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm465"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(74)90417-4"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2005.01219.x"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380809"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.2.944"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030152"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00298-4"}],"container-title":["Journal of Oral Pathology &amp; 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