{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:14:38Z","timestamp":1787508878745,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,1,23]],"date-time":"2009-01-23T00:00:00Z","timestamp":1232668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2009,4]]},"abstract":"<jats:p>\n                    <jats:bold>Background:\u2002<\/jats:bold>\n                    The origin of spindle cells (SC) in oral Kaposi\u2019s sarcoma (OKS) is still an intriguing aspect. Thus the aim of the present study was to compare the clinical, histological and immunohistochemical characteristics of OKS and oral pyogenic granuloma (OPG), in order to contribute to the knowledge of the cells involved in Kaposi\u2032s sarcoma pathogenesis.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:\u2002<\/jats:bold>\n                    In this retrospective, observational and comparative study, 39 OKS and 30 OPG cases were included. Immunohistochemical studies were performed for vimentin, \u03b1SMA, desmin, C\u2010kit, CD34, D2\u201040 and LANA\u20101 [human herpesvirus\u20108(HHV\u20108)]. Statistical comparisons were done using the chi\u2010square and Wilcoxon\u2013Mann\u2013Whitney rank sum tests.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:\u2002<\/jats:bold>\n                    Fourteen (35.9%) OKS cases also affected the skin, and 83.8% involved the palate. All OKS and OPG were positive for vimentin and CD34. OKS samples were positive for \u03b1SMA, and 25.6% expressed C\u2010kit. All OKS cases were positive for HHV\u20108, and the number of positive cells increased significantly from early\u200a\/\u200aintermediate to late histological stage. D2\u201040 was expressed in the cellular component and vascular walls of all OKS cases, but it was negative in OPG. HHV\u20108 expression was increased in late histological stages of OKS lesions.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:\u2002<\/jats:bold>\n                    The expression of D2\u201040 marker in the vascular walls and SC supports the view of a lymphatic differentiation in neoplastic cells of OKS. Desmin, \u03b1SMA\n                    <jats:italic>,<\/jats:italic>\n                    D2\u201040, C\u2010kit and HHV\u20108 were the main markers differently expressed in OKS and OPG.\n                  <\/jats:p>","DOI":"10.1111\/j.1600-0714.2008.00740.x","type":"journal-article","created":{"date-parts":[[2010,8,12]],"date-time":"2010-08-12T07:55:46Z","timestamp":1281599746000},"page":"328-333","source":"Crossref","is-referenced-by-count":22,"title":["Clinical, histological and immunohistochemical findings in oral Kaposi's sarcoma in a series of Mexican AIDS patients. Comparative study"],"prefix":"10.1111","volume":"38","author":[{"given":"V.","family":"Ram\u00edrez\u2010Amador","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Mart\u00ednez\u2010Mata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Gonz\u00e1lez\u2010Ram\u00edrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Anaya\u2010Saavedra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O. P.","family":"De Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,3,20]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2006.08.015"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.10-6-412"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000238411.75324.59"},{"key":"e_1_2_7_5_2","volume-title":"Globocan 2002 Database: Summary tables by cancer","author":"International Agency for Research on Cancer"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2006.01.002"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2002.290202.x"},{"key":"e_1_2_7_8_2","first-page":"240","article-title":"Human immunodeficiency virus\u2010associated oral Kaposi\u2019s sarcoma. 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