{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:37:42Z","timestamp":1778891862825,"version":"3.51.4"},"reference-count":54,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":1796,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,3]]},"DOI":"10.1111\/j.1600-0714.2010.00945.x","type":"journal-article","created":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T11:11:30Z","timestamp":1285931490000},"page":"218-226","source":"Crossref","is-referenced-by-count":20,"title":["Expression of DNA repair proteins, MSH2, MLH1 and MGMT in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patients\u2019 survival"],"prefix":"10.1111","volume":"40","author":[{"given":"Stamatios","family":"Theocharis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerzy","family":"Klijanienko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constantinos","family":"Giaginis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Jouffroy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelique","family":"Girod","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Point","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerasimos","family":"Tsourouflis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Sastre-Garau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,10,1]]},"reference":[{"key":"10.1111\/j.1600-0714.2010.00945.x-BIB1|cit1","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/S1368-8375(01)00109-9","article-title":"Oral cavity and pharynx cancer incidence in the United States, 1975-1988","volume":"38","author":"Canto","year":"2002","journal-title":"Oral Oncol"},{"key":"10.1111\/j.1600-0714.2010.00945.x-BIB2|cit2","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3322\/canjclin.57.1.43","article-title":"Cancer statistics","volume":"57","author":"Jemal","year":"2007","journal-title":"CA Cancer J Clin"},{"key":"10.1111\/j.1600-0714.2010.00945.x-BIB3|cit3","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/S0140-6736(02)11199-8","article-title":"Long-term survival rates of cancer patients achieved by the end of the 20th century: a period analysis","volume":"360","author":"Brenner","year":"2002","journal-title":"Lancet"},{"key":"10.1111\/j.1600-0714.2010.00945.x-BIB4|cit4","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1002\/cncr.20998","article-title":"Tongue and tonsil carcinoma: increasing trends in the U.S. population ages 20-44\u2003years","volume":"103","author":"Shiboski","year":"2005","journal-title":"Cancer"},{"key":"10.1111\/j.1600-0714.2010.00945.x-BIB5|cit5","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/s10555-007-9082-y","article-title":"Metastasis of squamous cell carcinoma of the oral tongue","volume":"26","author":"Sano","year":"2007","journal-title":"Cancer Metastasis Rev"},{"key":"10.1111\/j.1600-0714.2010.00945.x-BIB6|cit6","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1054\/bjoc.2000.1323","article-title":"Prognostic factors in tongue cancer-relative importance of demographic, clinical and histopathological factors","volume":"83","author":"Kantola","year":"2000","journal-title":"Br J Cancer"},{"key":"10.1111\/j.1600-0714.2010.00945.x-BIB7|cit7","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1038\/sj.bjc.6604633","article-title":"Ki-67 expression predicts locoregional recurrence in stage I oral tongue carcinoma","volume":"99","author":"Wangsa","year":"2008","journal-title":"Br J Cancer"},{"key":"10.1111\/j.1600-0714.2010.00945.x-BIB8|cit8","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/hed.10094","article-title":"Prognostic factors clinically stage I and II oral tongue carcinoma: a comparative study of stage, thickness, shape, growth pattern, invasive front malignancy grading, Martinez-Gimeno score and pathologic features","volume":"24","author":"Po Wing Yen","year":"2002","journal-title":"Head Neck"},{"key":"10.1111\/j.1600-0714.2010.00945.x-BIB9|cit9","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1445-2197.2008.04791.x","article-title":"Prognostic factors in the surgical treatment of patients with oral carcinoma","volume":"79","author":"Patel","year":"2009","journal-title":"ANZ J Surg"},{"key":"10.1111\/j.1600-0714.2010.00945.x-BIB10|cit10","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.joms.2005.11.094","article-title":"Tongue cancer: is there a difference in survival compared with other subsites in the oral cavity","volume":"65","author":"Bell","year":"2007","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1111\/j.1600-0714.2010.00945.x-BIB11|cit11","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.gde.2003.11.001","article-title":"The role of endogenous and exogenous DNA damage and mutagenesis","volume":"14","author":"Friedberg","year":"2004","journal-title":"Curr Opin Genet Dev"},{"key":"10.1111\/j.1600-0714.2010.00945.x-BIB12|cit12","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.taap.2006.03.008","article-title":"DNA repair systems as targets of cadmium toxicity","volume":"213","author":"Giaginis","year":"2006","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1111\/j.1600-0714.2010.00945.x-BIB13|cit13","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1101\/gad.1182704","article-title":"Cellular machineries for chromosomal DNA repair","volume":"18","author":"Peterson","year":"2004","journal-title":"Genes Dev"},{"key":"10.1111\/j.1600-0714.2010.00945.x-BIB14|cit14","first-page":"RA8","article-title":"DNA repair alterations in common pediatric malignancies","volume":"14","author":"Papaefthymiou","year":"2008","journal-title":"Med Sci Monit"},{"key":"10.1111\/j.1600-0714.2010.00945.x-BIB15|cit15","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.canlet.2007.10.026","article-title":"Low hMLH1 expression prior to definitive chemoradiotherapy predicts poor prognosis in esophageal squamous cell carcinoma","volume":"260","author":"Nam","year":"2008","journal-title":"Cancer Lett"},{"key":"10.1111\/j.1600-0714.2010.00945.x-BIB16|cit16","doi-asserted-by":"crossref","first-page":"168","DOI":"10.2310\/7070.2007.0015","article-title":"Significance and mechanism of microsatellite instability in laryngeal squamous cell carcinoma","volume":"36","author":"Zhigang","year":"2007","journal-title":"J Otolaryngol"},{"key":"10.1111\/j.1600-0714.2010.00945.x-BIB17|cit17","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1002\/cncr.22430","article-title":"Inactivation of human mutL homolog 1 and mutS homolog 2 genes in head and neck squamous cell carcinoma tumors and leukoplakia samples by promoter hypermethylation and its relation with microsatellite instability phenotype","volume":"109","author":"Sengupta","year":"2007","journal-title":"Cancer"},{"key":"10.1111\/j.1600-0714.2010.00945.x-BIB18|cit18","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1093\/annonc\/mdl048","article-title":"Microsatellite instability and methylation of the DNA mismatch repair genes in head and neck cancer","volume":"17","author":"Demokan","year":"2006","journal-title":"Ann Oncol"},{"key":"10.1111\/j.1600-0714.2010.00945.x-BIB19|cit19","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1002\/jso.20332","article-title":"Deficiency of hMLH1 and hMSH2 expression is a poor prognostic factor in esophageal squamous cell carcinoma","volume":"92","author":"Uehara","year":"2005","journal-title":"J Surg Oncol"},{"key":"10.1111\/j.1600-0714.2010.00945.x-BIB20|cit20","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1016\/j.jtcvs.2005.06.004","article-title":"Promoter methylation of the hMLH1 gene and protein expression of human mutL homolog 1 and human mutS homolog 2 in resected esophageal squamous cell carcinoma","volume":"130","author":"Tzao","year":"2005","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1111\/j.1600-0714.2010.00945.x-BIB21|cit21","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S1368-8375(02)00028-3","article-title":"Allelic imbalance at the DNA mismatch repair loci, hMSH2, hMLH1, hPMS1, hPMS2 and hMSH3, in squamous cell carcinoma of the head and neck","volume":"39","author":"Nunn","year":"2003","journal-title":"Oral Oncol"},{"key":"10.1111\/j.1600-0714.2010.00945.x-BIB22|cit22","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/ijc.11028","article-title":"Promoter hypermethylation profile of tumor-associated genes p16, p15, hMLH1, MGMT and E-cadherin in oral squamous cell carcinoma","volume":"105","author":"Viswanathan","year":"2003","journal-title":"Int J Cancer"},{"key":"10.1111\/j.1600-0714.2010.00945.x-BIB23|cit23","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0304-3835(98)00157-8","article-title":"Expression of hMSH2 correlates with in vitro chemosensitivity to CDDP cytotoxicity in oral and oropharyngeal carcinoma","volume":"132","author":"Fujieda","year":"1998","journal-title":"Cancer Lett"},{"key":"10.1111\/j.1600-0714.2010.00945.x-BIB24|cit24","first-page":"933","article-title":"Immunocytochemical detection of hMSH2 and hMLH1 expression in oral SCC","volume":"19","author":"Lo Muzio","year":"1999","journal-title":"Anticancer Res"},{"key":"10.1111\/j.1600-0714.2010.00945.x-BIB25|cit25","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.canlet.2009.08.007","article-title":"An epitome of DNA repair related genes and mechanisms in thyroid carcinoma","volume":"290","author":"Gatzidou","year":"2010","journal-title":"Cancer Lett"},{"key":"10.1111\/j.1600-0714.2010.00945.x-BIB26|cit26","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0921-8777(01)00088-X","article-title":"Molecular mechanisms of DNA mismatch repair","volume":"486","author":"Hsieh","year":"2001","journal-title":"Mut Res"},{"key":"10.1111\/j.1600-0714.2010.00945.x-BIB27|cit27","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/jcp.10077","article-title":"DNA mismatch repair and mutation avoidance pathways","volume":"191","author":"Marti","year":"2002","journal-title":"J Cell Physiol"},{"key":"10.1111\/j.1600-0714.2010.00945.x-BIB28|cit28","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S1470-2045(02)00649-6","article-title":"Emerging pathways in colorectal cancer development","volume":"3","author":"Haydon","year":"2002","journal-title":"Lancet Oncol"},{"key":"10.1111\/j.1600-0714.2010.00945.x-BIB29|cit29","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1158\/1055-9965.EPI-07-0733","article-title":"Aberrant DNA methylation of P16, MGMT, and hMLH1 genes in combination with MTHFR C677T genetic polymorphism in esophageal squamous cell carcinoma","volume":"17","author":"Wang","year":"2008","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1111\/j.1600-0714.2010.00945.x-BIB30|cit30","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.oraloncology.2006.05.007","article-title":"MGMT expression in oral precancerous and cancerous lesions: correlation with progression, nodal metastasis and poor prognosis","volume":"43","author":"Sawhney","year":"2007","journal-title":"Oral Oncol"},{"key":"10.1111\/j.1600-0714.2010.00945.x-BIB31|cit31","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.canlet.2006.01.015","article-title":"Loss of expression of DNA repair enzyme MGMT in oral leukoplakia and early oral squamous cell carcinoma. A prognostic tool?","volume":"245","author":"Rodr\u00edguez","year":"2007","journal-title":"Cancer Lett"},{"key":"10.1111\/j.1600-0714.2010.00945.x-BIB32|cit32","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1080\/15287390701290725","article-title":"Reduced expression of human DNA repair genes in esophageal squamous-cell carcinoma in china","volume":"70","author":"Liu","year":"2007","journal-title":"J Toxicol Environ Health A"},{"key":"10.1111\/j.1600-0714.2010.00945.x-BIB33|cit33","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1007\/s00432-006-0122-8","article-title":"Aberrant promoter hypermethylation of p16 and MGMT genes in oral squamous cell carcinomas and the surrounding normal mucosa","volume":"132","author":"Kato","year":"2006","journal-title":"Cancer Res Clin Oncol"},{"key":"10.1111\/j.1600-0714.2010.00945.x-BIB34|cit34","first-page":"615","article-title":"Promoter hypermethylation and inactivation of O(6)-methylguanine-DNA methyltransferase in esophageal squamous cell carcinomas and its reactivation in cell lines","volume":"26","author":"Fang","year":"2005","journal-title":"Int J Oncol"},{"key":"10.1111\/j.1600-0714.2010.00945.x-BIB35|cit35","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1093\/carcin\/bgg062","article-title":"Inactivation of DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation and its relation to p53 mutations in esophageal squamous cell carcinoma","volume":"24","author":"Zhang","year":"2003","journal-title":"Carcinogenesis"},{"key":"10.1111\/j.1600-0714.2010.00945.x-BIB36|cit36","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/35077232","article-title":"Genome maintenance mechanisms for preventing cancer","volume":"411","author":"Hoeijmakers","year":"2001","journal-title":"Nature"},{"key":"10.1111\/j.1600-0714.2010.00945.x-BIB37|cit37","first-page":"371","article-title":"Deficient expression of O(6)-methylguanine-DNA methyltransferase combined with mismatch-repair proteins hMLH1 and hMSH2 is related to poor prognosis in human biliary tract carcinoma","volume":"9","author":"Kohya","year":"2002","journal-title":"Ann Surg Oncol"},{"key":"10.1111\/j.1600-0714.2010.00945.x-BIB38|cit38","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1007\/s10434-001-0807-9","article-title":"Expression and prognostic significance of O6-methylguanine-DNA methyltransferase in hepatocellular, gastric, and breast cancers","volume":"8","author":"Matsukura","year":"2001","journal-title":"Ann Surg Oncol"},{"key":"10.1111\/j.1600-0714.2010.00945.x-BIB39|cit39","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1002\/jso.10209","article-title":"Combined loss of expression of O6-methylguanine-DNA methyltransferase and hMLH1 accelerates progression of hepatocellular carcinoma","volume":"82","author":"Matsukura","year":"2003","journal-title":"J Surg Oncol"},{"key":"10.1111\/j.1600-0714.2010.00945.x-BIB40|cit40","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1111\/j.1365-2559.2008.02999.x","article-title":"Prognostic significance of DNA repair proteins MLH1, MSH2 and MGMT expression in non-small-cell lung cancer and precursor lesions","volume":"52","author":"Cooper","year":"2008","journal-title":"Histopathology"},{"key":"10.1111\/j.1600-0714.2010.00945.x-BIB41|cit41","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1097\/01.pas.0000149687.90710.21","article-title":"Oral squamous cell carcinoma: histological risk assessment, but not margin status, is strongly predictive of local disease-free and overall survival","volume":"29","author":"Brandwein-Gensler","year":"2005","journal-title":"Am J Surg Pathol"},{"key":"10.1111\/j.1600-0714.2010.00945.x-BIB42|cit42","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1159\/000227604","article-title":"The relationship of shape of tumor invasion to depth of invasion and cervical lymph node metastasis in squamous cell carcinoma of the tongue","volume":"54","author":"Shintani","year":"1997","journal-title":"Oncology"},{"key":"10.1111\/j.1600-0714.2010.00945.x-BIB43|cit43","volume-title":"World Health Organization classifications tumours. Pathology and genetics of head and neck tumours","author":"Barnes","year":"2005"},{"key":"10.1111\/j.1600-0714.2010.00945.x-BIB44|cit44","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0002-9610(00)00433-5","article-title":"A comparison of prognostic significance of tumor diameter, length, width, thickness area, volume and clinicopathological features of oral tongue carcinoma","volume":"180","author":"Po Wing Yen","year":"2000","journal-title":"Am J Surg"},{"key":"10.1111\/j.1600-0714.2010.00945.x-BIB45|cit45","first-page":"88","article-title":"Expression and methylation profile of DNA repair genes in Greek colon adenocarcinoma patients","volume":"455","author":"Michailidi","year":"2009","journal-title":"Virchows Arch"},{"key":"10.1111\/j.1600-0714.2010.00945.x-BIB46|cit46","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1471-230X-9-14","article-title":"Heat shock protein-27, -60 and -90 expression in gastric cancer: association with clinicopathological variables and patient survival","volume":"9","author":"Giaginis","year":"2009","journal-title":"BMC Gastroenterol"},{"key":"10.1111\/j.1600-0714.2010.00945.x-BIB47|cit47","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s12253-009-9221-6","article-title":"Clinical significance of ephrin (Eph)-A1, -A2, -A4, -A5 and -A7 receptors in pancreatic ductal adenocarcinoma","volume":"16","author":"Giaginis","year":"2010","journal-title":"Pathol Oncol"},{"key":"10.1111\/j.1600-0714.2010.00945.x-BIB48|cit48","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s10555-005-5044-4","article-title":"Epidemiology of head and neck cancer: magnitude of the problem","volume":"24","author":"D\u00f6brossy","year":"2005","journal-title":"Cancer Metastasis Rev"},{"key":"10.1111\/j.1600-0714.2010.00945.x-BIB49|cit49","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s10555-005-5051-5","article-title":"Progression of head and neck squamous cell cancer","volume":"24","author":"T\u00edm\u00e1r","year":"2005","journal-title":"Cancer Metastasis Rev"},{"key":"10.1111\/j.1600-0714.2010.00945.x-BIB50|cit50","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.dnarep.2010.02.006","article-title":"Polymorphisms of the DNA repair gene MGMT and risk and progression of head and neck cancer","volume":"9","author":"Zhang","year":"2010","journal-title":"DNA Repair (Amst)"},{"key":"10.1111\/j.1600-0714.2010.00945.x-BIB51|cit51","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.amjoto.2004.06.007","article-title":"Aberrant promoter hypermethylation of multiple genes in head and neck squamous cell carcinoma","volume":"26","author":"Puri","year":"2005","journal-title":"Am J Otolaryngol"},{"key":"10.1111\/j.1600-0714.2010.00945.x-BIB52|cit52","doi-asserted-by":"crossref","first-page":"5089","DOI":"10.1158\/1078-0432.CCR-07-0119","article-title":"Association between hypermethylated tumor and paired surgical margins in head and neck squamous cell carcinomas","volume":"13","author":"Martone","year":"2007","journal-title":"Clin Cancer Res"},{"key":"10.1111\/j.1600-0714.2010.00945.x-BIB53|cit53","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1158\/1055-9965.967.13.6","article-title":"O6-methylguanine-DNA methyltransferase gene: epigenetic silencing and prognostic value in head and neck squamous cell carcinoma","volume":"13","author":"Zuo","year":"2004","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1111\/j.1600-0714.2010.00945.x-BIB54|cit54","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1007\/s10120-003-0213-z","article-title":"Loss of expression of DNA repair enzymes MGMT, hMLH1 and hMSH2 during tumor progression in gastric cancer","volume":"6","author":"Kitajima","year":"2003","journal-title":"Gastric Cancer"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0714.2010.00945.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/j.1600-0714.2010.00945.x\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T04:38:57Z","timestamp":1740544737000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0714.2010.00945.x"}},"subtitle":["MSH2, MLH1 and MGMT and mobile tongue carcinoma"],"short-title":[],"issued":{"date-parts":[[2010,10,1]]},"references-count":54,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,3]]}},"URL":"https:\/\/doi.org\/10.1111\/j.1600-0714.2010.00945.x","relation":{},"ISSN":["0904-2512"],"issn-type":[{"value":"0904-2512","type":"print"}],"subject":[],"published":{"date-parts":[[2010,10,1]]}}}