{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T02:50:23Z","timestamp":1776653423063,"version":"3.51.2"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,12,24]],"date-time":"2010-12-24T00:00:00Z","timestamp":1293148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:p> <jats:italic>J Oral Pathol Med<\/jats:italic> (2010) <jats:bold>40<\/jats:bold>: 385\u2013389<\/jats:p><jats:p><jats:bold>Background:\u2002<\/jats:bold> Cyclooxygenase\u20102 expression is associated with unfavorable outcome in various cancers, and evidence is accumulating that carcinogenesis possibly evolves from intracellular changes in response to induction of this enzyme. Today selective cyclooxygenase\u20102 inhibitors are being studied and used as complement in cancer treatment. This study examined the prognostic value of cyclooxygenase\u20102 expression in oral tongue squamous cell carcinoma (OTSCC).<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Expression of cyclooxygenase\u20102 was determined in biopsies from 76 stage matched patients with OTSCC by immunohistochemistry between January 2000 and December 2004 in Stockholm, Sweden. Additionally, twelve samples taken after pre\u2010operative radiotherapy were investigated.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> All OTSCC specimen expressed cyclooxygenase\u20102 by immunostaining. The cyclooxygenase\u20102 staining intensity increased significantly with more advanced stage (<jats:italic>P<\/jats:italic>\u2003=\u20030.020). Fifty percent of the surgical specimen showed a decrease in immunostaining post\u2010radiation (<jats:italic>P<\/jats:italic>\u2003=\u20030.031). No association was found with survival.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Cyclooxygenase\u20102 expression has limited prognostic value in OTSCC.<\/jats:p>","DOI":"10.1111\/j.1600-0714.2010.00992.x","type":"journal-article","created":{"date-parts":[[2011,4,12]],"date-time":"2011-04-12T11:22:07Z","timestamp":1302607327000},"page":"385-389","source":"Crossref","is-referenced-by-count":9,"title":["Cyclooxygenase\u20102 expression in oral tongue squamous cell 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