{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:25:22Z","timestamp":1791645922162,"version":"4.3.4"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,2,22]],"date-time":"2011-02-22T00:00:00Z","timestamp":1298332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:p> <jats:italic>J Oral Pathol Med<\/jats:italic> (2011) <jats:bold>40<\/jats:bold>: 380\u2013384<\/jats:p><jats:p><jats:bold>Background:\u2002<\/jats:bold> Perforin and granzyme B (GB) are the main constituents of cytotoxic T\u2010lymphocyte granules, and they have important roles in preventing the initiation and progression of cancer.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> The aim of this study was to compare the expression of CD8<jats:sup>+<\/jats:sup>\/perforin<jats:sup>+<\/jats:sup> double\u2010staining and GB<jats:sup>+<\/jats:sup> cells, by immunohistochemistry, in primary oral cavity squamous cell carcinoma (OCSCC), lip squamous cell carcinoma (LSCC), non\u2010dysplastic leukoplakia (LK), dysplastic LK, actinic cheilitis (AC), oral lichen planus (LP) and normal oral mucosa.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Our results showed a higher expression of CD8<jats:sup>+<\/jats:sup>\/perforin<jats:sup>+<\/jats:sup> and GB<jats:sup>+<\/jats:sup> cells in LSCC when compared with the samples of OCSCC, non\u2010dysplastic and dysplastic LK, AC, oral LP and normal oral mucosa. In addition, increased CD8<jats:sup>+<\/jats:sup>\/perforin<jats:sup>+<\/jats:sup> and GB<jats:sup>+<\/jats:sup> cell numbers were observed in all pre\u2010malignant lesions (non\u2010dysplastic LK, dysplastic LK, AC) when compared with the control.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Perforin and GB proteins may contribute to antitumoural immunity, leading to the direct killing of tumour cells; however, it seems to occur more effectively in LSCC than OCSCC.<\/jats:p>","DOI":"10.1111\/j.1600-0714.2011.01014.x","type":"journal-article","created":{"date-parts":[[2011,2,22]],"date-time":"2011-02-22T18:20:39Z","timestamp":1298398839000},"page":"380-384","source":"Crossref","is-referenced-by-count":16,"title":["Distinct expression of perforin and granzyme B in lip and oral cavity squamous cell carcinoma"],"prefix":"10.1111","volume":"40","author":[{"given":"N\u00e1dia Lago","family":"Costa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9ia Souza","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nath\u00e1lia Caroline","family":"Souza\u2010Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00eds Gustavo","family":"Jaime\u2010Paiva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula","family":"Junqueira\u2010Kipnis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarc\u00edlia Aparecida","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elismauro Francisco","family":"Mendon\u00e7a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline Carvalho","family":"Batista","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,2,22]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"397","volume-title":"Cellular and molecular immunology","author":"Abbas AK","year":"2008"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2010.00908.x"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2010.00907.x"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2010.00896.x"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2009.11.016"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2009.00792.x"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2009.212"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2009.206"},{"key":"e_1_2_7_10_2","first-page":"87","article-title":"Granzyme B as a prognostic marker of cervical intraepithelial neoplasia","volume":"26","author":"Kondo MC","year":"2005","journal-title":"Eur J Gynaecol Oncol"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2006.07.003"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23543"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2009.10.034"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(98)00019-0"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2003.08.007"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6690780"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-2637"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0714.2011.01014.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0714.2011.01014.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T04:01:56Z","timestamp":1697342516000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0714.2011.01014.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,22]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,5]]}},"alternative-id":["10.1111\/j.1600-0714.2011.01014.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0714.2011.01014.x","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,22]]}}}