{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T19:27:57Z","timestamp":1785871677424,"version":"3.56.0"},"reference-count":55,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,10,17]],"date-time":"2011-10-17T00:00:00Z","timestamp":1318809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:p><jats:italic>J Oral Pathol Med<\/jats:italic> (2012) <jats:bold>41<\/jats:bold>: 96\u2013105<\/jats:p><jats:p><jats:bold>Background:\u2002<\/jats:bold> Local effects of intra\u2010articular (IA) injection of anti\u2010rabbit tumor necrosis factor alpha monoclonal antibody (anti\u2010TNF\u03b1 mAb) for antigen\u2010induced mono\u2010arthritis (AIA) of the rabbit temporomandibular joint (TMJ) and its systemic influences were evaluated.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Biochemical analysis of synovial fluid (SF), clinical and histopathological analyses of TMJ, and serum analysis were performed after inducing AIA in bilateral TMJs of 40 New Zealand White rabbits. IA injection of anti\u2010TNF\u03b1 mAb in unilateral TMJ (TNF blockade side; <jats:italic>n<\/jats:italic>\u2003=\u200312) and IgG (<jats:italic>n<\/jats:italic>\u2003=\u200312) was performed while saline injected on the contralateral side. TNF\u03b1 and IL\u20101\u03b2 in SF was analyzed at Days 1, 3, 7, and 21. Joint swelling and head withdrawal reflex threshold (WRT) over TMJs were evaluated in TNF blockade side (<jats:italic>n<\/jats:italic>\u2003=\u200312) with histopathological analysis at Days 3, 7, and 21. In remaining four animals with TNF blockade, TNF\u03b1 and anti\u2010TNF\u03b1 mAb in serum were analyzed.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Tumor necrosis factor alpha in SF was significantly lower in TNF blockade side on all days but IL\u20101\u03b2 was lower only on Day 3. WRT was significantly higher at all times in the blockade side. Less inflammatory reactions and degenerative changes of cartilage were observed on Days 7 and 21 in the blockade side. TNF\u03b1 and anti\u2010TNF\u03b1 mAb were under detection level in serum at all times.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Intra\u2010articular injection of anti\u2010rabbit TNF\u03b1 mAb in mono\u2010arthritis model was effective to control local inflammation and degenerative joint changes. Further, low\u2010dose IA injection of antibody may not have systemic side effects.<\/jats:p>","DOI":"10.1111\/j.1600-0714.2011.01056.x","type":"journal-article","created":{"date-parts":[[2011,10,17]],"date-time":"2011-10-17T13:46:45Z","timestamp":1318859205000},"page":"96-105","source":"Crossref","is-referenced-by-count":12,"title":["Local effects of intra\u2010articular injection of anti\u2010rabbit tumor necrosis factor alpha monoclonal antibody in antigen\u2010induced arthritis of the rabbit temporomandibular joint"],"prefix":"10.1111","volume":"41","author":[{"given":"Taishi","family":"Ohtani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Habu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Khanal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izumi","family":"Yoshioka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Matsukawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Tominaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,10,17]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-009-9659-4"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1693"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.105775"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.058347"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.332.7542.639"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.52.12.870"},{"key":"e_1_2_5_8_2","first-page":"554","article-title":"Osteoarthritis and rheumatoid arthritis pannus have similar qualitative metabolic characteristics and pro\u2010inflammatory cytokine response","volume":"26","author":"Furuzawa\u2010Carballeda J.","year":"2008","journal-title":"Clin. 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