{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T04:20:45Z","timestamp":1783138845192,"version":"3.54.6"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,7,8]],"date-time":"2011-07-08T00:00:00Z","timestamp":1310083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:p><jats:italic>J Oral Pathol Med<\/jats:italic> (2012) <jats:bold>41<\/jats:bold>: 73\u201379<\/jats:p><jats:p><jats:bold>Background:\u2002<\/jats:bold> One of the factors involved in the pathogenesis of Beh\u00e7et disease (BD) and recurrent aphthous ulcerations (RAU) is a cell\u2010mediated immune response in which several cytokines (interleukin\u20102, interleukin\u20106) and T regulatory cell (T reg cell) population seem to play a major role. The aim of this study was to measured the interleukin\u20102 (IL\u20102), interleukin\u20106 (IL\u20106) levels and analysis of CD4<jats:sup>+<\/jats:sup>\u2003CD25<jats:sup>+<\/jats:sup>\u2003Foxp\u20103<jats:sup>+<\/jats:sup> Treg cells in peripheral blood from patients with BD and RAU. In addition; we also analysed peripheral blood from healthy subjects for comparison.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Thirty patients (15 men and 15 women) with BD, 30 patients (12 men and 18 women) with RAU and 15 healthy control subjects (nine men and six women) participated in the study. Analysis of CD4<jats:sup>+<\/jats:sup>\u2003CD25<jats:sup>+<\/jats:sup>\u2003Foxp\u20103<jats:sup>+<\/jats:sup> Treg cells, IL\u20102 and IL\u20106 levels have been measured in flow cytometry.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> No statistical differences were observed in the serum levels of IL\u20102 and IL\u20106 between BD and RAU patients, and healthy subjects. Although there were no statistical differences in the number of CD4<jats:sup>+<\/jats:sup>\u2003CD25<jats:sup>+<\/jats:sup> Foxp\u20103<jats:sup>+<\/jats:sup> cells between groups, there were statistically significant differences in the number of CD4<jats:sup>+<\/jats:sup>\u2003CD25<jats:sup>bright<\/jats:sup> Treg cells. CD4<jats:sup>+<\/jats:sup>\u2003CD25<jats:sup>bright<\/jats:sup> Treg cells were significantly increased in BD and RAU patients compared to healthy subjects. Statistical analysis revealed no difference according to the number of CD4<jats:sup>+<\/jats:sup>\u2003CD25<jats:sup>bright<\/jats:sup> cells between BD and RAU patients.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> These results indicate that CD4<jats:sup>+<\/jats:sup> CD25<jats:sup>bright<\/jats:sup> T regulatory cells may be contributing factor in the pathogenesis of BD and RAU.<\/jats:p>","DOI":"10.1111\/j.1600-0714.2011.01061.x","type":"journal-article","created":{"date-parts":[[2011,7,8]],"date-time":"2011-07-08T16:53:55Z","timestamp":1310144035000},"page":"73-79","source":"Crossref","is-referenced-by-count":45,"title":["Interleukin\u20102, interleukin\u20106 and T regulatory cells in peripheral blood of patients with Beh\u00e7et\u2019s disease and recurrent aphthous ulcerations"],"prefix":"10.1111","volume":"41","author":[{"given":"Filiz Namdar","family":"Pekiner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emre","family":"Aytugar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulderen Yanikkaya","family":"Demirel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Oguz","family":"Borahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,7,8]]},"reference":[{"key":"e_1_2_5_3_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1999.01069.x"},{"key":"e_1_2_5_3_3_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016358509046497"},{"key":"e_1_2_5_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1990.tb05447.x"},{"key":"e_1_2_5_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2005.01.002"},{"key":"e_1_2_5_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2008.00661.x"},{"key":"e_1_2_5_3_7_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065X.2001.1820102.x"},{"key":"e_1_2_5_3_8_2","doi-asserted-by":"publisher","DOI":"10.3109\/s10165-008-0064-x"},{"key":"e_1_2_5_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1178"},{"key":"e_1_2_5_3_10_2","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.212.101"},{"key":"e_1_2_5_3_11_2","doi-asserted-by":"crossref","first-page":"596","DOI":"10.47102\/annals-acadmedsg.V33N5p596","article-title":"Serum interleukin\u20102, interleukin\u20106, tumour necrosis factor\u2010alpha and nitric oxide levels in patients with Beh\u00e7et\u2019s disease","volume":"33","author":"Akdeniz N","year":"2004","journal-title":"Ann Acad Med Singapore"},{"key":"e_1_2_5_3_12_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.193.11.1285"},{"key":"e_1_2_5_3_13_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.193.11.1303"},{"key":"e_1_2_5_3_14_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.3.1245"},{"key":"e_1_2_5_3_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2009.01608.x"},{"key":"e_1_2_5_3_16_2","first-page":"116","article-title":"Expression of interleukin\u20102 by activated peripheral blood lymphocytes upregulated by plasma level of interleukin\u20102 in patients with recurrent aphthous ulcers","volume":"24","author":"Sun A","year":"2000","journal-title":"Proc Natl Sci Counc Repub China B"},{"key":"e_1_2_5_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2007.07.201"},{"key":"e_1_2_5_3_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20334"},{"key":"e_1_2_5_3_19_2","first-page":"55","article-title":"Evaluation of T cell subsets in Beh\u00e7et\u2019s syndrome using anti\u2010T cell monoclonal antibodies","volume":"60","author":"Valesini G","year":"1985","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_5_3_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1988.tb01539.x"},{"key":"e_1_2_5_3_21_2","first-page":"1078","article-title":"Criteria for diagnosis of Beh\u00e7et\u2019s disease","volume":"335","author":"International Study Group for Beh\u00e7et\u2019s disease","year":"1990","journal-title":"Lancet"},{"key":"e_1_2_5_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(72)90211-3"},{"key":"e_1_2_5_3_23_2","volume-title":"Procedures for collections of diagnostic blood specimens by venipuncture; 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