{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T01:14:40Z","timestamp":1772241280226,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,9,13]],"date-time":"2011-09-13T00:00:00Z","timestamp":1315872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:p><jats:italic>J Oral Pathol Med<\/jats:italic> (2012) <jats:bold>41<\/jats:bold>: 194\u2013199<\/jats:p><jats:p><jats:bold>Background:\u2002<\/jats:bold> Peripheral giant cell lesion (PGCL) is a reactive process associated with a local irritating factor that shows low recurrence after treatment, especially if the irritating factor is eliminated. On the other hand, central giant cell lesion (CGCL) presents a variable clinical behavior ranging from slow and asymptomatic growth without recurrence to rapid, painful and recurrent growth. Our aim was to compare the immunoexpression of tumor necrosis factor\u2010alpha (TNF\u2010\u03b1) and transforming growth factor\u2010beta (TGF\u2010\u03b2) in CGCL and PGCL.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Twenty CGCL and 20 PGCL were selected for analysis of the immunoexpression of TNF\u2010\u03b1 and TGF\u2010\u03b2 in multinucleated giant cells (MGC) and mononucleated cells (MC).<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The PGCL showed lightly higher expression of TNF\u2010\u03b1 than CGCL. In comparison with PGCL, the CGCL showed higher expression of TGF\u2010\u03b2 in MC and MGC (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05) and in total cells (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). Significant positive correlation was found between expressions of TGF\u2010\u03b2 and TNF\u2010\u03b1 in CGCL (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05).<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Our results suggest that, in CGCL, coordinated interactions between TGF\u2010\u03b2 and TNF\u2010\u03b1 may be important for osteoclastogenesis and bone resorption. PGCL occasionally cause bone resorption but to a lower extent, a fact that might be explained by the lower expression of TGF\u2010\u03b2 in these lesions.<\/jats:p>","DOI":"10.1111\/j.1600-0714.2011.01075.x","type":"journal-article","created":{"date-parts":[[2011,9,13]],"date-time":"2011-09-13T16:47:57Z","timestamp":1315932477000},"page":"194-199","source":"Crossref","is-referenced-by-count":13,"title":["Immunoexpression of TNF\u2010\u03b1 and TGF\u2010\u03b2 in central and peripheral giant cell lesions of the jaws"],"prefix":"10.1111","volume":"41","author":[{"given":"Felipe Rodrigues","family":"de Matos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maiara","family":"de Moraes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cassiano Francisco Weege","family":"Nonaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e9lia Batista","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roseana","family":"de Almeida Freitas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,9,13]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2010.00993.x"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.scs.0000171965.39734.e8"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2003.00069.x"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2000.tb00319.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.151.4.879"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2007.08.032"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2008.11.005"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(97)90291-3"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2007.00690.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.182.1.361"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2009.00855.x"},{"key":"e_1_2_5_13_2","first-page":"104","article-title":"Granuloma perif\u00e9rico de c\u00e9lulas gigantes \u2013 imunohistoqu\u00edmica anti\u2010tnf\u2010alfa","volume":"17","author":"Resende CRS","year":"2007","journal-title":"Rev Periodontia"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2008.01499.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/BLO.0b013e31804b4131"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/CRD.0b013e3181b04698"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401470"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-006-9021-3"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.72.9.3666"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1808-8694(15)31133-2"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650040116"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/0470846658.ch16"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008198200"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00835.x"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0196-9781(95)02030-6"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.113.13.2445"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.1200"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.67.1.227"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.7.3679"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.04.038"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0806517"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.190.2.293"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.9.4957"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.19.14608"},{"key":"e_1_2_5_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.11.120"},{"key":"e_1_2_5_36_2","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevEukarGeneExpr.v20.i2.10"}],"container-title":["Journal of Oral Pathology &amp; 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