{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:22:48Z","timestamp":1793146968149,"version":"4.5.0"},"reference-count":54,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,9,22]],"date-time":"2011-09-22T00:00:00Z","timestamp":1316649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:p><jats:italic>J Oral Pathol Med<\/jats:italic> (2012) <jats:bold>41<\/jats:bold>: 90\u201395<\/jats:p><jats:p><jats:bold>Background:\u2002<\/jats:bold> Oral lichen planus (OLP), which is a chronic inflammatory disease of the oral mucosa with unknown etiology, affects about 2% of the population. MicroRNAs are small non\u2010coding RNAs involved in normal processes such as development and differentiation as well as progression of human diseases. The aim of this study was to investigate the expression of miR\u201021, miR\u2010125b, and miR\u2010203 and to compare RNA levels of their potential targets, the tumor suppressor p53 and its relative p63, both known to be deregulated in OLP.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> In biopsies from 20 patients with OLP and 20 age\u2010 and sex\u2010matched healthy controls, epithelium was laser dissected and analyzed for the expression of miR\u201021, miR\u2010125b, miR\u2010203, p53, and p63 using qRT\/PCR.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Increased expression of miR\u201021 and miR\u2010203, decreased expression of miR\u2010125, and down\u2010regulation of p53 and \u0394Np63 RNA were seen in OLP compared to normal oral mucosa. When comparing microRNA expression to levels of p53 and p63 RNA, a significant negative correlation was seen between \u0394Np63 and miR\u2010203 and between miR\u201021 and p53, respectively.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Results indicate a role for the studied microRNAs in changes seen in OLP.<\/jats:p>","DOI":"10.1111\/j.1600-0714.2011.01084.x","type":"journal-article","created":{"date-parts":[[2011,9,27]],"date-time":"2011-09-27T13:42:15Z","timestamp":1317130935000},"page":"90-95","source":"Crossref","is-referenced-by-count":40,"title":["Altered expression of miR\u201021, miR\u2010125b, and miR\u2010203 indicates a role for these microRNAs in oral lichen planus"],"prefix":"10.1111","volume":"41","author":[{"given":"K.","family":"Danielsson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. 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