{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T21:54:37Z","timestamp":1724968477975},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,11,16]],"date-time":"2011-11-16T00:00:00Z","timestamp":1321401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p><jats:italic>J Oral Pathol Med<\/jats:italic> (2012) <jats:bold>41<\/jats:bold>: 315\u2013321<\/jats:p><jats:p><jats:bold>Objective:\u2002<\/jats:bold> To investigate the effectiveness of pimecrolimus treatment in patients not responding to corticosteroid treatment and to investigate its effect on Fas expression on keratinocytes in oral lichen planus (OLP).<\/jats:p><jats:p><jats:bold>Subjects and Methods:\u2002<\/jats:bold> Twenty patients with OLP were recruited from the Oral Medicine Clinic at the School of Dentistry, Ain Shams University, Egypt. Pimecrolimus 1% cream with a hydrophilic adhesive gel base was applied to the oral lesions, four times daily, for a total of 2\u2003months. A marker lesion was identified and assessed by clinical scoring (CS). The symptomatology score was obtained using a visual analog scale (VAS). Pre\u2010treatment and post\u2010treatment specimens were immunohistochemically stained for detecting Fas.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The results of clinical scores showed statistically high significant improvement (<jats:italic>P\u2003=\u2003<\/jats:italic>0.0001). The mean VAS decreased significantly over time as well as the mean of Fas expression (<jats:italic>P\u2003&lt;\u2003<\/jats:italic>0.05<jats:italic>)<\/jats:italic>. The overall percentage of reduction from baseline to week 8 was 87%, 93%, and 67% for clinical scores, visual analog score, and Fas expression, respectively.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Topical pimecrolimus reduced Fas expression, and it appears to be a promising alternative treatment for OLP.<\/jats:p>","DOI":"10.1111\/j.1600-0714.2011.01099.x","type":"journal-article","created":{"date-parts":[[2011,11,17]],"date-time":"2011-11-17T01:09:08Z","timestamp":1321492148000},"page":"315-321","source":"Crossref","is-referenced-by-count":11,"title":["Topical pimecrolimus effect on Fas inducing apoptosis in oral lichen planus: a clinical immunohistochemical study"],"prefix":"10.1111","volume":"41","author":[{"given":"Suzan S.","family":"Ibrahim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hala H.","family":"Hazzaa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,11,16]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1016\/j.tripleo.2006.11.001","article-title":"Oral lichen planus and oral lichenoid lesions: diagnostic and therapeutic considerations","volume":"103","author":"Al\u2010Hashimi I","year":"2007","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2007.07.199"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2006.09.006"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.120452"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(03)00305-6"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2003.00077.x"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2004.06.077"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1999.tb01994.x"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.03.012"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.143.4.472"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2003.00130.x"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(76)90113-5"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1999.tb02016.x"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(99)00029-9"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1997.tb00453.x"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2005.02.005"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2005.00373.x"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2007.02387.x"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202X.2003.22108.x"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.88.11.969"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05559.x"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.01.044"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.142.8.1066"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0007-0963.2004.05884.x"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0007-0963.2004.05875.x"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.4.627"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.06.022"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08726.x"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2010.02.030"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.01.054"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-006-0059-7"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.142.9.1233"}],"container-title":["Journal of Oral Pathology &amp; 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