{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:28:21Z","timestamp":1777498101526,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,11,16]],"date-time":"2011-11-16T00:00:00Z","timestamp":1321401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p><jats:italic>J Oral Pathol Med<\/jats:italic> (2012) <jats:bold>41<\/jats:bold>: 348\u2013353<\/jats:p><jats:p><jats:bold>Background:\u2002<\/jats:bold> Neurovascular hamartoma (NVH), in particular in the oral cavity, is rarely described in the literature. The low number of cases may reflect a genuine rarity of the lesion, or it may be due to its being unrecognized and\/or under\u2010reported.<\/jats:p><jats:p><jats:bold>Objectives:\u2002<\/jats:bold> To investigate clinical and microscopic features of oral NVH and to define microscopic diagnostic criteria with emphasis on the differential diagnosis.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Archival cases diagnosed as oral NVH between 1999 and 2011 were retrieved; clinical and demographic data were collected, and a paired morphometric analysis was conducted, with each case of NVH a case of fibrous hyperplasia (FH) from the same oral location. The nerve bundle and blood vessel density were quantified in five microscopic fields at \u00d7100 magnification.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The study group included 25 oral NVH, 11 men and 14 women, aged 6\u201376\u2003years, (mean 44). The majority occurred in the tongue (54%), followed by the buccal mucosa and lower lip (17% each), clinically presenting as asymptomatic 0.25\u20132.5\u2003cm exophytic masses. Microscopic characteristics included poorly circumscribed masses of closely packed nerve bundles and blood vessels in a loose matrix, containing minimal or no inflammation.<\/jats:p><jats:p>The mean nerve bundle density was significantly higher in NVH (4.28\u2003\u00b1\u20031.26) in comparison with FH (0.27\u2003\u00b1\u20030.27), (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.00001), and mean vessel density was significantly lower (5.98\u2003\u00b1\u20031.4 vs. 7.8\u2003\u00b1\u20031.9, respectively), (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0003).<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Oral NVH may not be as rare as previously considered. Morphometric analysis demonstrated that NVH presents a separate distinct entity.<\/jats:p>","DOI":"10.1111\/j.1600-0714.2011.01101.x","type":"journal-article","created":{"date-parts":[[2011,11,17]],"date-time":"2011-11-17T01:09:26Z","timestamp":1321492166000},"page":"348-353","source":"Crossref","is-referenced-by-count":20,"title":["Oral neurovascular hamartoma: a lesion searching for a name"],"prefix":"10.1111","volume":"41","author":[{"given":"Irit","family":"Allon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dror M.","family":"Allon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avraham","family":"Hirshberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Shlomi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"Lifschitz\u2010Mercer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilana","family":"Kaplan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,11,16]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"1649","volume-title":"Surgical pathology of the head and neck","author":"Fertilo A","year":"2001"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2007.00518.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-263x.1999.00116.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1258\/002221503322334620"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3180674dd7"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(98)90295-5"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2000.107058"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5876(94)90015-9"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajoms.2010.03.001"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-2358.2008.00228.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5876(95)01216-8"},{"key":"e_1_2_6_13_2","doi-asserted-by":"crossref","first-page":"984","DOI":"10.5858\/2008-132-984-GCITOA","article-title":"Glial choristoma in the oral and maxillofacial region","volume":"132","author":"Li\u2010Sha S","year":"2008","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00179000"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2001.300607.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-008-0865-0"},{"key":"e_1_2_6_17_2","first-page":"21","article-title":"Neurovascular hamartoma","volume":"15","author":"Lee A","year":"2009","journal-title":"Dermatol Online J"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199410000-00006"},{"key":"e_1_2_6_19_2","first-page":"672","article-title":"An unusual form of neurovascular hamartoma","volume":"69","author":"Hruban Z","year":"1960","journal-title":"Arch Pathol"},{"key":"e_1_2_6_20_2","first-page":"31","volume-title":"Pathologic basis of disease","author":"Cotran RS","year":"1992"},{"key":"e_1_2_6_21_2","first-page":"635","volume-title":"Walter & Israel general pathology","author":"Walter JB","year":"1996"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01536163"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1080\/00313020600561989"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.110134"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kjms.2010.09.007"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2001.112304"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2003.52"},{"key":"e_1_2_6_28_2","first-page":"237","article-title":"Benign mesenchymomas of the head and neck","volume":"102","author":"Bures C","year":"1978","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09072.x"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2004.07.003"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-009-0714-2"},{"key":"e_1_2_6_32_2","volume-title":"Online Mendelian Inheritance in Man, OMIM (TM)","author":"National Center for Biotechnology Information, National Library of Medicine","year":"2000"}],"container-title":["Journal of Oral Pathology &amp; 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