{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T10:30:19Z","timestamp":1722508219188},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,11,16]],"date-time":"2011-11-16T00:00:00Z","timestamp":1321401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p><jats:italic>J Oral Pathol Med<\/jats:italic> (2012) <jats:bold>41<\/jats:bold>: 354\u2013360<\/jats:p><jats:p><jats:bold>Background:\u2002<\/jats:bold> We previously developed a rat trigeminal motor neuron axotomy model involving masseter and temporal muscle resection to study pathological changes of the central nucleus after peripheral nerve injury caused by oral surgery. Because motor neurons are reported to be more vulnerable to axotomy in mice than rats, we compared the degeneration process of the trigeminal motor nucleus in the rat model with a similar mouse model.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> We removed masseter and temporal muscles of adult mice or rats. Animals were sacrificed at 3, 7, 14, 28, 42, and 56\u2003days post\u2010operation, and the trigeminal motor nuclei were histologically analyzed.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Size reduction, but no neuronal loss, was seen in the trigeminal motor nuclei in both mice and rats. Time\u2010dependent Noxa expression, starting at 1\u2003week post\u2010operation (wpo), was seen in the mouse model. By 8\u2003wpo, mice expressed a higher level of Noxa than rats. Additionally, we noted persistent expression of cleaved caspase\u20103 in mice but not in rats. Conversely, apoptosis\u2010inducing factor (AIF), which executes DNA fragmentation in the nucleus, was not translocated to the nucleus in either model.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Our findings indicate differential activation of motor neuron apoptosis pathways after axotomy in mice and rats. Lack of activation of caspase\u2010independent pathways and distal end denervation in our model might be related to the survival of motor neurons after axonal injury. These findings could be relevant to future neuroprotective strategies for peripheral nerve injury caused by oral surgeries.<\/jats:p>","DOI":"10.1111\/j.1600-0714.2011.01109.x","type":"journal-article","created":{"date-parts":[[2011,11,17]],"date-time":"2011-11-17T01:09:46Z","timestamp":1321492186000},"page":"354-360","source":"Crossref","is-referenced-by-count":1,"title":["Differential activation of proapoptotic molecules between mouse and rat models of distal motor trigeminal denervation"],"prefix":"10.1111","volume":"41","author":[{"given":"Shiori","family":"Harada","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi O.","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Seki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiji","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Iwaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,11,16]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1679\/aohc1950.35.175"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(95)00505-6"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05748.x"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2006.1891"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0266-4356(03)00068-8"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-5182(05)80316-6"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.PRS.0000131872.90767.50"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199809020-00009"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197911000-00020"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3302665"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004410050690"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490230315"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(93)90287-P"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/345440a0"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902680209"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2010.08.005"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4041-04.2005"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.080466"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2009.00772.x"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/34112"},{"key":"e_1_2_5_22_2","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1523\/JNEUROSCI.5475-03.2004","article-title":"Ischemic preconditioning: neuronal survival in the face of caspase\u20103 activation","volume":"24","author":"Tanaka H","year":"2004","journal-title":"J Neurosci"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0800628105"},{"key":"e_1_2_5_24_2","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.1073\/pnas.040556597","article-title":"Caspase\u20103: a vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson\u2019s disease","volume":"97","author":"Andreas H","year":"2000","journal-title":"PNAS"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/35069004"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.14.5.729"}],"container-title":["Journal of Oral Pathology &amp; 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