{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T13:12:27Z","timestamp":1769692347434,"version":"3.49.0"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,11,16]],"date-time":"2011-11-16T00:00:00Z","timestamp":1321401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:p><jats:italic>J Oral Pathol Med<\/jats:italic> (2012) <jats:bold>41<\/jats:bold>: 394\u2013399<\/jats:p><jats:p><jats:bold>Background:\u2002<\/jats:bold> Oral tongue squamous cell carcinoma (OTSCC) often metastasizes to cervical lymph nodes. Mechanisms of this disease progression are not fully known. We aimed at finding new predictive markers for diagnosis and disease monitoring.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Seventy\u2010three consecutive T1N0M0 and T2N0M0 OTSCC patients treated at Helsinki University Central Hospital, Helsinki, Finland, in 1992\u20132002 were included. Tissue array blocks were prepared from primary tumors and immunostained. Immunoexpression of matrix metalloproteinase (MMP)\u20102, \u20108, \u20109, and \u201013 was compared with patient characteristics and outcome.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Nuclear expression of MMP\u201013, but not cytoplasmic expression of MMP\u20102, \u20108, and \u20109, was associated with invasion depth (<jats:italic>P\u2003<\/jats:italic>=<jats:italic>\u2003<\/jats:italic>0.017) and tumor size (<jats:italic>P\u2003<\/jats:italic>=<jats:italic>\u2003<\/jats:italic>0.008). Furthermore, high nuclear MMP\u201013 expression was predictive of poor outcome (<jats:italic>P\u2003<\/jats:italic>=<jats:italic>\u2003<\/jats:italic>0.042).<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Our results suggest that especially MMP\u201013 may be regarded as a prognostic biomarker in OTSCC.<\/jats:p>","DOI":"10.1111\/j.1600-0714.2011.01110.x","type":"journal-article","created":{"date-parts":[[2011,11,17]],"date-time":"2011-11-17T01:13:23Z","timestamp":1321492403000},"page":"394-399","source":"Crossref","is-referenced-by-count":44,"title":["Prognostic significance of matrix metalloproteinase\u20102, \u20108, \u20109, and \u201013 in oral tongue cancer"],"prefix":"10.1111","volume":"41","author":[{"given":"Laura 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