{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:16:57Z","timestamp":1791155817408,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,11,16]],"date-time":"2011-11-16T00:00:00Z","timestamp":1321401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:p><jats:italic>J Oral Pathol Med<\/jats:italic> (2012) <jats:bold>41<\/jats:bold>: 408\u2013414<\/jats:p><jats:p><jats:bold>Background:\u2002<\/jats:bold> Odontogenic keratocysts (OKCs) constitute between 1.8% and 21.5% of odontogenic cysts and are associated with higher propensity to recur than other odontogenic cysts following surgical removal. Previous studies have been performed to identify clinico\u2010pathological predictive factors in relation to such behaviour. The relationship between the presence of hyalinisation and recurrence of the OKC has not been explored.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> A total of 110 OKCs were selected, comprising 53 non\u2010recurrent cases, 50 cases known to subsequently recur and seven syndromic cases. Cases were examined blind, and histological assessment of the epithelial lining, connective tissue capsule and cyst lumen was made. Statistical analysis was completed using Pearson Chi\u2010square, Fisher\u2019s exact test and logistic regression analysis.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Subepithelial hyalinisation of the underlying connective tissue capsule (<jats:italic>P\u2003<\/jats:italic>=<jats:italic>\u2003<\/jats:italic>0.006) was significantly more common in OKC that recurred. Recurring cysts demonstrating hyalinisation were seen in a younger age group (mean\u2003=\u200340.8\u2003years) than the non\u2010recurrent cysts (mean\u2003=\u200356.4\u2003years). In addition, subepithelial splitting (<jats:italic>P<\/jats:italic>\u2003=\u20030.015) and the position of mitotic figures (<jats:italic>P<\/jats:italic>\u2003=\u20030.033) were more common in recurring cysts.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> In this case series, several differences were found in relation to histological features of recurring and non\u2010recurring OKCs. There are many factors responsible for the high recurrence rate of OKCs, and the presence of subepithelial hyalinisation may be used as an additional histopathological feature to predict a greater tendency for recurrence.<\/jats:p>","DOI":"10.1111\/j.1600-0714.2011.01113.x","type":"journal-article","created":{"date-parts":[[2011,11,16]],"date-time":"2011-11-16T23:40:22Z","timestamp":1321486822000},"page":"408-414","source":"Crossref","is-referenced-by-count":46,"title":["Histopathological features that predict the recurrence of odontogenic keratocysts"],"prefix":"10.1111","volume":"41","author":[{"given":"Hannah E.","family":"Cottom","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faten I.","family":"Bshena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Speight","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey T.","family":"Craig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam V.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,11,16]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"963","article-title":"Om keratocyster (kolesteatom) I Kaeberne","volume":"60","author":"Philipsen HP","year":"1956","journal-title":"Tandlaegebladet"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/9780470759769.ch3"},{"key":"e_1_2_6_4_2","first-page":"88","volume-title":"Investigative Pathology of the Odontogenic Cysts","author":"Browne RM","year":"1991"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0503(81)80049-5"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1975.tb01738.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0278-2391(84)90390-2"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(01)00065-3"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.940"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/00220345000790061101"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510379016"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2010.01.012"},{"key":"e_1_2_6_13_2","first-page":"306","volume-title":"Pathology and Genetics. 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