{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T04:58:10Z","timestamp":1768539490055,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,12,22]],"date-time":"2011-12-22T00:00:00Z","timestamp":1324512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:p><jats:italic>J Oral Pathol Med<\/jats:italic> (2012) <jats:bold>41<\/jats:bold>: 500\u2013504<\/jats:p><jats:p><jats:bold>Background:\u2002<\/jats:bold> Atrophic glossitis (AG) is considered to be a marker of nutritional deficiency. In this study, we evaluated whether there was an intimate association of the deficiency of hemoglobin, iron, vitamin B12 or folic acid, high blood homocysteine level, and serum gastric parietal cell antibody (GPCA) positivity with AG.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> The blood hemoglobin, iron, vitamin B12, folic acid, and homocysteine concentrations and the serum GPCA level in 176 AG patients were measured and compared with the corresponding levels in 176 age\u2010 and sex\u2010matched healthy control subjects.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> We found that 39 (22.2%), 47 (26.7%), 13 (7.4%), and 3 (1.7%) AG patients had deficiencies of Hb (men\u2003&lt;\u200313\u2003g\/dl, women\u2003&lt;\u200312\u2003g\/dl), iron (&lt;60\u2003\u03bcg\/dl), vitamin B12 (&lt;200\u2003pg\/ml), and folic acid (&lt;4\u2003ng\/ml), respectively. Moreover, 38 (21.6%) AG patients had abnormally high blood homocysteine level, and 47 (26.7%) AG patients had serum GPCA positivity. AG patients had a significantly higher frequency of Hb, iron, or vitamin B12 deficiency, of abnormally elevated blood homocysteine level, or of serum GPCA positivity than healthy control subjects (all <jats:italic>P<\/jats:italic>\u2010values\u2003=\u20030.000). However, no significant difference in frequency of folic acid deficiency was found between AG patients and healthy control subjects.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> We conclude that there is a significant association of deficiency of hemoglobin, iron and vitamin B12, abnormally high blood homocysteine level, and serum GPCA positivity with AG.<\/jats:p>","DOI":"10.1111\/j.1600-0714.2011.01122.x","type":"journal-article","created":{"date-parts":[[2011,12,22]],"date-time":"2011-12-22T07:22:08Z","timestamp":1324538528000},"page":"500-504","source":"Crossref","is-referenced-by-count":64,"title":["Significant association of deficiency of hemoglobin, iron and vitamin B12, high homocysteine level, and gastric parietal cell antibody positivity with atrophic glossitis"],"prefix":"10.1111","volume":"41","author":[{"given":"Andy","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hung\u2010Pin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Ping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun\u2010Pin","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,12,22]]},"reference":[{"key":"e_1_2_5_2_2","volume-title":"Oral and maxillofacial pathology","author":"Neville BW","year":"2009"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/29.1.47"},{"key":"e_1_2_5_4_2","first-page":"335","article-title":"Incidence of tongue diseases based on epidemiologic studies (review of the literature)","volume":"85","author":"Dombi C","year":"1992","journal-title":"Fogorv Sz"},{"key":"e_1_2_5_5_2","first-page":"199","article-title":"Some local and systemic factors related to tongue inflammation","volume":"85","author":"J\u00e4rvinen J","year":"1989","journal-title":"Proc Finn Dent Soc"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(82)90281-X"},{"key":"e_1_2_5_7_2","volume-title":"Preliminary finding of the first health and nutrition examination survey, United States 1971\u20131972","author":"National Center for Health Statistics","year":"1975"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(97)00076-6"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1976.tb01774.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2005.00324.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2001.300909.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/85.1.193"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2002.00117.x"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2008.00686.x"},{"key":"e_1_2_5_15_2","volume-title":"Iron deficiency anaemia assessment, prevention, and control: a guide for programme managers","author":"WHO\/UNICEF\/UNU","year":"2001"},{"key":"e_1_2_5_16_2","first-page":"2455","article-title":"Microcytic anemia","volume":"55","author":"Shine JW","year":"1997","journal-title":"Am Fam Physician"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/15648265080292S129"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.5121"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa060900"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199804093381507"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.53.6.731"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197409122911101"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.appet.2005.01.001"}],"container-title":["Journal of Oral Pathology &amp; 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