{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:16:58Z","timestamp":1791155818512,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,1,27]],"date-time":"2012-01-27T00:00:00Z","timestamp":1327622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:p><jats:italic>J Oral Pathol Med<\/jats:italic> (2012) <jats:bold>41<\/jats:bold>: 630\u2013636<\/jats:p><jats:p><jats:bold>Background:\u2002<\/jats:bold> Several cell types are associated with the development of cystic and tumoral odontogenic lesions. Among inflammatory cells, mast cells can be associated with their pathogenesis. The aim of this study was to analyze mast cells in periapical cysts, dentigerous cysts, and keratocystic odontogenic tumors.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Tissue sections were submitted to toluidine blue staining and immunohistochemistry with antibody anti\u2010tryptase (clone G3). Mast cells were quantitated using Image\u2010Pro Plus software to obtain the mean number of mast cells in three regions: epithelial, superficial portion of the fibrous wall and deep portion of the fibrous wall from 20 periapical cysts, 20 dentigerous cysts (six non\u2010inflamed and 14 inflamed) and 20 keratocystic odontogenic tumors (four non\u2010inflamed and 16 inflamed).<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The mean number of mast cells detected per lesion by immunohistochemistry (4.1) was higher than by histochemistry (1.5) (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001). Inflamed dentigerous cysts and keratocystic odontogenic tumors showed a higher mean number of mast cells than non\u2010inflamed lesions in all regions. The deep region from all cysts showed the highest mean number of degranulated mast cells, except for non\u2010inflamed keratocystic odontogenic tumors analyzed by immunohistochemistry.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Immunohistochemical staining detected higher number of mast cells than histochemistry. The higher number of mast cells observed in inflamed lesions could indicate the participation of these cells in the inflammatory response in odontogenic lesions. The prevalence of degranulated mast cells in the deep region suggests intense activity of these cells, possibly related to growth of cystic lesions.<\/jats:p>","DOI":"10.1111\/j.1600-0714.2012.01126.x","type":"journal-article","created":{"date-parts":[[2012,1,27]],"date-time":"2012-01-27T06:47:41Z","timestamp":1327646861000},"page":"630-636","source":"Crossref","is-referenced-by-count":24,"title":["Evaluation of mast cells in periapical cysts, dentigerous cysts, and keratocystic odontogenic tumors"],"prefix":"10.1111","volume":"41","author":[{"given":"Juliana","family":"de Noronha Santos Netto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1bio Ram\u00f4a","family":"Pires","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliene Carvalho","family":"da Fonseca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lic\u00ednio Esmeraldo","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"de Queiroz Chaves Louren\u00e7o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,27]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"89","article-title":"Odontogenic cysts. 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