{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:25:36Z","timestamp":1790018736725,"version":"4.0.1"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,3,7]],"date-time":"2012-03-07T00:00:00Z","timestamp":1331078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p><jats:italic>J Oral Pathol Med<\/jats:italic> (2012) <jats:bold>41<\/jats:bold>: 517\u2013523<\/jats:p><jats:p>The aim of this study was to characterize the expression of Toll\u2010like receptors (TLRs) during the development of sialoadenitis in the non\u2010obese diabetic mouse. Submandibular glands were dissected from non\u2010obese diabetic mice at 4, 8, 10, 12, and 16\u2003weeks of age. The mRNA expression levels of TLR1, 2, 3, 4, 5, 6, 7, 8, 9, 11, 12, 13, MyD88, and TRIF was quantified using real\u2010time reverse transcription polymerase chain reaction. The mRNA expression levels in 4\u2010week\u2010old non\u2010obese diabetic mice were used as controls. The expression levels of TLR1, 2, 4, and 9 were significantly higher at 8, 10, 12, and 16\u2003weeks than the levels in the controls. The expression level of TLR3 was significantly higher at 16\u2003weeks than in the controls. A group of mice were given drinking water containing 4.75% chloroquine starting at 4\u2003weeks. Chloroquine caused a significant decrease in the expression of TLR1, 2, 3, 4, and 9 at 16\u2003weeks compared with control mice who did not receive chloroquine. The areas of lymphocyte infiltration seen on serial sections of submandibular glands in the mice receiving chloroquine were significantly smaller than the areas of infiltration in control glands. Increased expression of Toll\u2010like receptors may be involved in the development and\/or progression of sialoadenitis in the non\u2010obese diabetic mouse. Toll\u2010like receptors may be a therapeutic target for autoimmune sialoadenitis.<\/jats:p>","DOI":"10.1111\/j.1600-0714.2012.01136.x","type":"journal-article","created":{"date-parts":[[2012,3,7]],"date-time":"2012-03-07T10:25:12Z","timestamp":1331115912000},"page":"517-523","source":"Crossref","is-referenced-by-count":16,"title":["Involvement of toll\u2010like receptors in autoimmune sialoadenitis of the non\u2010obese diabetic mouse"],"prefix":"10.1111","volume":"41","author":[{"given":"Shigeyoshi","family":"Shimizu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihito","family":"Kurashige","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiko","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mami","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Saitoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Selimovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Abiko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,3,7]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66990-5"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2009.01582.x"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.2174\/138945009789735101"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.08.062"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yadr.2008.09.004"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.2217\/thy.09.2"},{"key":"e_1_2_5_8_2","first-page":"1019","article-title":"Toll\u2010like receptor in salivary glands from patients with Sj\u00f6gren\u2019s syndrome: functional analysis by human salivary gland cell line","volume":"34","author":"Kawakami A","year":"2007","journal-title":"J Reumatol"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2006.03311.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2008.00700.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/154411130201300103"},{"key":"e_1_2_5_12_2","first-page":"90","article-title":"Increased expression of beta\u2010defensin 2 and 3 during the development of autoimmune sialoadenitis in MRL\/lpr mice","volume":"29","author":"Saitoh M","year":"2007","journal-title":"Med Mol Morphol"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2009.09.009"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-010-0833-1"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2009.04071.x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1107794"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2008.00630.x"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00461.2007"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2003.12.006"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1447.039"},{"key":"e_1_2_5_21_2","doi-asserted-by":"crossref","first-page":"485","DOI":"10.3748\/wjg.v12.i3.485","article-title":"Role of nitric oxide in Toll\u2010like receptor 2 and 4 mRNA expression in liver of acute hemorrhagic necrotizing pancreatitis rats","volume":"12","author":"Zang L","year":"2006","journal-title":"World J Gastroenterol"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-10-2634"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201002021"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09782"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/781235"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1159\/000109767"}],"container-title":["Journal of Oral Pathology &amp; 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