{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:24:24Z","timestamp":1763036664705},"reference-count":47,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2012,3,14]],"date-time":"2012-03-14T00:00:00Z","timestamp":1331683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:p><jats:italic>J Oral Pathol Med<\/jats:italic> (2012) <jats:bold>41<\/jats:bold>: 721\u2013727<\/jats:p><jats:p>Wegener\u2019s granulomatosis is one of the anti\u2010cytoplasmic autoantibodies (ANCA)\u2010associated vasculitides. Although it typically affects the lungs and kidneys, the head and neck are also involved in most cases but the site usually affected is the upper airway. However, there are 35 cases with well\u2010documented clinicopathological data in which Wegener\u2019s granulomatosis manifested in the major salivary glands, most commonly the parotid. Twenty\u2010four patients presented with salivary signs and symptoms, in eight of whom there was no other presenting manifestation. These signs and symptoms may mimic infection or neoplasia and laboratory investigations, including ANCA serology and histopathology, may be non\u2010specific; thus, in 21 of the 35 patients (60%) there was a delay in diagnosis. Amongst the 21 were 11 of the 14 (78.6%) patients who presented with unilateral parotid disease and three of the five who died. Three other patients suffered permanent pulmonary, two renal and five facial nerve damage. This article reviews the literature on major salivary gland involvement in Wegener\u2019s granulomatosis, which should be considered in the differential diagnosis of major salivary gland disease particularly if commoner causes have been excluded. A detailed medical history, and persistently inconclusive laboratory tests, could provide the clues that enable prompt diagnosis.<\/jats:p>","DOI":"10.1111\/j.1600-0714.2012.01141.x","type":"journal-article","created":{"date-parts":[[2012,3,14]],"date-time":"2012-03-14T17:24:42Z","timestamp":1331745882000},"page":"721-727","source":"Crossref","is-referenced-by-count":22,"title":["Wegener\u2019s granulomatosis of the major salivary glands"],"prefix":"10.1111","volume":"41","author":[{"given":"A. 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