{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T03:34:42Z","timestamp":1768793682798,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,4,24]],"date-time":"2012-04-24T00:00:00Z","timestamp":1335225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:p><jats:italic>J Oral Pathol Med<\/jats:italic> (2012) <jats:bold>41<\/jats:bold>: 598\u2013602<\/jats:p><jats:p><jats:bold>Background:\u2002<\/jats:bold> Salivary gland carcinomas are a heterogeneous group of tumors with varying malignant potential. In this study, we evaluated the proliferative marker Ki\u201067 in salivary gland carcinomas and related the Ki\u201067 index to clinical data.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> A total of 176 salivary gland carcinomas of 13 different subtypes were stained immunohistochemically for Ki\u201067. The number of Ki\u201067 positive cells was counted and the Ki\u201067 index was calculated as the percentage of positive tumor cells.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The Ki\u201067 median value was 26 (range 1\u201399). The median follow\u2010up time was 6.9\u2003years (range 0\u201319\u2003years). The 5\u2010 and 10\u2010year crude survival was 70% and 59%, respectively. In univariate analysis, Ki\u201067 index, stage, vascular invasion and tumor grade were significantly related to crude survival, but in multivariate analysis only Ki\u201067 index, age, and stage were independent prognostic factors.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> We showed that irrespective of subtyping, grading or morphological appearance of tumor, the Ki\u201067 index is an important and independent prognosticator. Clinical and histo\u2010pathological data must be considered, when planning the treatment of the individual patient. We have shown that besides stage and age of the patient, Ki\u201067 is a strong, independent prognostic factor.<\/jats:p>","DOI":"10.1111\/j.1600-0714.2012.01148.x","type":"journal-article","created":{"date-parts":[[2012,4,24]],"date-time":"2012-04-24T18:31:58Z","timestamp":1335292318000},"page":"598-602","source":"Crossref","is-referenced-by-count":27,"title":["Prognostic significance of Ki\u201067 in salivary gland carcinomas"],"prefix":"10.1111","volume":"41","author":[{"given":"Stine Rosenkilde","family":"Larsen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristine","family":"Bj\u00f8rndal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Godballe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annelise","family":"Krogdahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,4,24]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2011.04.020"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/003655402\/000028047"},{"key":"e_1_2_5_4_2","volume-title":"Head and Neck Tumours","author":"Barnes L","year":"2011"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199703)181:3<323::AID-PATH780>3.0.CO;2-K"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199704000-00019"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2011.02.022"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/07357900802088968"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/02841860500543208"},{"key":"e_1_2_5_10_2","first-page":"7","article-title":"Cell proliferation in salivary gland tumors","volume":"142","author":"Skalova A","year":"1996","journal-title":"Gen Diagn Pathol"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0347(200008)22:5<489::AID-HED8>3.0.CO;2-X"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10400"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2011.01023.x"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1080\/00016480510003174"},{"key":"e_1_2_5_15_2","first-page":"161","article-title":"Prognostic relevance of cell proliferation in major salivary gland carcinomas","volume":"25","author":"Suzzi MV","year":"2005","journal-title":"Acta Otorhinolaryngol Ital"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348941011901006"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2007.02719.x"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdh299"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0964-1955(96)00077-2"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800831228"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2005.02.005"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2009.10.016"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(94)90014-0"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711730104"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(97)80029-5"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2009.03.021"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0714.2012.01148.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0714.2012.01148.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T05:32:48Z","timestamp":1698643968000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0714.2012.01148.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,24]]},"references-count":25,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["10.1111\/j.1600-0714.2012.01148.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0714.2012.01148.x","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,24]]}}}