{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T09:01:33Z","timestamp":1784019693806,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,5,3]],"date-time":"2012-05-03T00:00:00Z","timestamp":1336003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:p><jats:italic>J Oral Pathol Med<\/jats:italic> (2012) <jats:bold>41<\/jats:bold>: 689\u2013696<\/jats:p><jats:p><jats:bold>Background:\u2002<\/jats:bold> The aim of this study was to investigate the roles of Matrix Metalloproteinases (MMP)\u20102, Metalloproteinases\u20107, Metalloproteinases\u201010 and Tissue Inhibitors of Metalloproteinase\u20101 (TIMP\u20101) in the pathogenesis of oral lichen planus (OLP) disease in same tissue samples.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Thirty\u2010nine individuals [29 patients with OLP (74%) and 10 healthy control subjects (25%)] were included in our study. The mean age was 48\u2003\u00b1\u200314.39 with a range of 20\u201375.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> MMP\u20102 and MMP\u20107 expression was significantly different in the patient and control groups in the epithelium and the connective tissue (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030. 05). The ratio of MMP\u20102\/TIMP\u20101 and MMP\u20107\/TIMP\u20101 were higher in patient with OLP group than control group.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Along with the exposure of the role of MMPs activity on diseases characterized by the tissue destruction, several studies were conducted on the pharmacological control of MMPs activity. However, understanding of the biological functions of MMPs is very important for the development and implementation of MMP inhibitors in the treatment of diseases. According to the results of this study, we suggest that MMP\u20102, MMP\u20107, and TIMP\u20101 may be involved in the formation of OLP lesions. Further studies on MMPs may be useful for understanding and treating the diseases such as OLP.<\/jats:p>","DOI":"10.1111\/j.1600-0714.2012.01160.x","type":"journal-article","created":{"date-parts":[[2012,5,3]],"date-time":"2012-05-03T12:31:40Z","timestamp":1336048300000},"page":"689-696","source":"Crossref","is-referenced-by-count":16,"title":["The roles of matrix metalloproteinases\u20102, \u20107, \u201010 and tissue inhibitor of metalloproteinase\u20101 in the pathogenesis of oral lichen planus"],"prefix":"10.1111","volume":"41","author":[{"given":"Asli Hayirlioglu","family":"Rubaci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakki 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