{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T20:19:08Z","timestamp":1793305148776,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2012,5,19]],"date-time":"2012-05-19T00:00:00Z","timestamp":1337385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:p><jats:italic>J Oral Pathol Med<\/jats:italic> (2012) <jats:bold>41<\/jats:bold>: 748\u2013754<\/jats:p><jats:p><jats:bold>Background:\u2002<\/jats:bold> The development of betel\u2010quid (BQ) processing industry in Hunan has increased the usage of this substance and may produce significant health consequences. However, the update data for the prevalence of BQ chewing and its effect on oral submucous fibrosis (OSF) are limited.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> A population\u2010based survey was conducted to investigate the prevalence of BQ chewing and OSF in Hunan. A questionnaire interview and an oral examination were conducted. A multivariate logistic regression model was used to study the effect of socio\u2010demographic characteristics on area\u2010specific behaviors of BQ chewing.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> A total of 2356 subjects participated in this survey, with a 78.5% of response rate. The lifetime prevalence of BQ chewing was 16.2% (2.9% for ex\u2010chewers and 13.3% for current\u2010chewers). The findings from multivariate logistic regression model showed that a higher prevalence of this habit was among individuals who were males, urban residents, 15\u201349\u2003years old, educated for 9\u201312\u2003years, smokers, and drinkers. Male chewers occupied a fairly higher percentage of the combined use of tobacco and\/or alcohol (86.1\u201387.5%) than the non\u2010chewers (50.6\u201356.7%). The overall prevalence of OSF was 1.0%. Compared with the subjects without OSF (1.7\u201323.2%), a significantly higher proportion of OSF patients were a current\u2010chewer (62.3% in men and 100.0% in women).<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> BQ chewing is a vital risk factor for OSF in Hunan. A high prevalence of BQ chewing found among the younger cohort (15\u201349\u2003years old) is an urgent warning for this oral premalignant disorder.<\/jats:p>","DOI":"10.1111\/j.1600-0714.2012.01166.x","type":"journal-article","created":{"date-parts":[[2012,5,20]],"date-time":"2012-05-20T13:02:48Z","timestamp":1337518968000},"page":"748-754","source":"Crossref","is-referenced-by-count":41,"title":["Betel\u2010quid and oral submucous fibrosis: a cross\u2010sectional study in Hunan province, China"],"prefix":"10.1111","volume":"41","author":[{"given":"Shan\u2010Shan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Hui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Jun","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi\u2010Wen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie\u2010Qing","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian\u2010You","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,5,19]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1360-0443.2002.00024.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600727"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1995.tb01132.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70326-2"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-0823"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2011.01022.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20619"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23264"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27401"},{"key":"e_1_2_6_11_2","volume-title":"IARC Monograph on the evaluation of carcinogenic risks to humans, Betel\u2010quid and Areca\u2010nut chewing and some Areca\u2010nut\u2010derived nitrosamines","author":"World Health Organization","year":"2004"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/83.5.1153"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/87.5.1204"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-004-1532-2"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980008003339"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2008.01.003"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-3506(99)00152-3"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1080\/13556210020091437"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1992.tb01007.x"},{"key":"e_1_2_6_20_2","first-page":"1","article-title":"Profile of the betel\/tobacco quid chewers in six Malaysian estates","volume":"7","author":"Tan BS","year":"2000","journal-title":"Annal Dent Univ Malaya"},{"key":"e_1_2_6_21_2","first-page":"12","article-title":"Oral submucous fibrosis \u2013 case reports","volume":"1","author":"Jian XC","year":"1985","journal-title":"J Clin Stomatol"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.1997.tb00918.x"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2008.00640.x"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25809"},{"key":"e_1_2_6_25_2","first-page":"113","article-title":"Oral submucous fibrosis in India: a new epidemic?","volume":"11","author":"Gupta PC","year":"1998","journal-title":"Natl Med J India"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.1985.tb00468.x"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196707)20:7<1141::AID-CNCR2820200717>3.0.CO;2-4"},{"key":"e_1_2_6_28_2","first-page":"130","article-title":"Three cases of oral cancer associated with oral submucous fibrosis","volume":"18","author":"Jian XC","year":"2000","journal-title":"West China J Stomatol"},{"key":"e_1_2_6_29_2","first-page":"130","article-title":"A study of 335 cases of oral submucous fibrosis","volume":"11","author":"Tang JQ","year":"1993","journal-title":"West China J Stomatol"},{"key":"e_1_2_6_30_2","first-page":"119","article-title":"A retrospective study of malignant transformation of oral submucous fibrosis","volume":"21","author":"Gao YJ","year":"2005","journal-title":"J Clin Stomatol"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0714.2012.01166.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0714.2012.01166.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T09:31:14Z","timestamp":1698658274000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0714.2012.01166.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,19]]},"references-count":29,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["10.1111\/j.1600-0714.2012.01166.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0714.2012.01166.x","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,19]]}}}