{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T21:28:16Z","timestamp":1785446896882,"version":"3.56.0"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2012,5,31]],"date-time":"2012-05-31T00:00:00Z","timestamp":1338422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:p><jats:italic>J Oral Pathol Med<\/jats:italic> (2012) <jats:bold>41<\/jats:bold>: 755\u2013761<\/jats:p><jats:p><jats:bold>Background and objectives:\u2002<\/jats:bold> Oral submucous fibrosis (OSMF) is a potentially malignant disorder of the oral mucosa, mainly associated with the practice of chewing gutka and betel quid. The pathogenesis is obscure, and till date, no definitive therapy is available for the management of OSMF. Hence, this preliminary study was carried out to compare the efficacy of Aloe vera with antioxidants in the treatment for OSMF.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Twenty study subjects with OSMF were included in the study. Patients were divided into two groups. There were 10 patients in each group; group A subjects received 5\u2003mg of aloe vera gel to be applied topically three times daily for 3\u2003months and group B subjects received antioxidant capsules twice daily for 3\u2003months. The results were analyzed with paired \u2018<jats:italic>t<\/jats:italic>\u2019 test and unpaired \u2018<jats:italic>t<\/jats:italic>\u2019 test.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Aloe vera responded better in all the parameters assessed and responded in all the clinicohistopathological stages particularly in those with mild\u2010stage clinically and early\u2010stage histopathologically. Aloe vera showed a statistically significant reduction in burning sensation (<jats:italic>P<\/jats:italic>\u2003=\u20030.008), improvement in mouth opening (<jats:italic>P<\/jats:italic>\u2003=\u20030.02), and cheek flexibility (<jats:italic>P<\/jats:italic>\u2003=\u20030.01) on comparing with the antioxidant group.<\/jats:p><jats:p><jats:bold>Interpretation and conclusion:\u2002<\/jats:bold> Overall assessment of the parameters depicted that Aloe vera group showed a better treatment response compared to the antioxidants group. It reduces the burning sensation and improves mouth opening thereby enhanced the patients\u2019 compliance. It proves to be a relatively safe, can be applied topically, easily available, economical, noninvasive, and efficacious in the treatment for OSMF.<\/jats:p>","DOI":"10.1111\/j.1600-0714.2012.01168.x","type":"journal-article","created":{"date-parts":[[2012,5,31]],"date-time":"2012-05-31T11:59:26Z","timestamp":1338465566000},"page":"755-761","source":"Crossref","is-referenced-by-count":60,"title":["Aloe vera in the treatment for oral submucous fibrosis \u2013 a preliminary study"],"prefix":"10.1111","volume":"41","author":[{"given":"Ramachandran","family":"Sudarshan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajeshwari G.","family":"Annigeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Sree 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