{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T13:02:22Z","timestamp":1782306142558,"version":"3.54.5"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2012,5,15]],"date-time":"2012-05-15T00:00:00Z","timestamp":1337040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:p><jats:italic>J Oral Pathol Med<\/jats:italic> (2012) <jats:bold>41<\/jats:bold>: 736\u2013740<\/jats:p><jats:p><jats:bold>Background:\u2002<\/jats:bold> The aim of this study was to evaluate oxidative stress status in the saliva of patients with oral lichen planus (OLP) and oral squamous cell carcinoma (OSCC).<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Thirty\u2010two patients with OLP, 26 patients with OSCC, and 30 non\u2010involved subjects were enrolled in this study. The study was conducted at the Cancer Department, Clinic of Oral Medicine, Tehran University of Medical Sciences. The unstimulated whole saliva malondialdehyde (MDA), as an indicator of lipid peroxidation, the total antioxidant capacity (TAC), and 8\u2010hydroxy\u20102\u2032\u2010deoxyguanosine (8\u2010OHdG) were assayed by thiobarbituric acid, ferric reducing antioxidant potential (FRAP), and ELISA method, respectively. The TAC\/MDA ratio was used as an index of oxidative stress status. Data were analyzed by ANOVA followed by the Tukey\u2019s <jats:italic>post hoc<\/jats:italic> test.<\/jats:p><jats:p><jats:bold>Results and Conclusion:\u2002<\/jats:bold> There were no significant differences in saliva TAC and MDA levels between OLP and control, and also between OLP and OSCC patients. MDA and 8\u2010OHdG were significantly higher but TAC was lower in OSCC patients than control. TAC\/MDA ratio was significantly lower in patients with OSCC than both OLP patients and control. TAC\/MDA ratio was significantly lower but 8\u2010OHdG was higher in patients with OLP compared to control. This suggests that patients with OLP and OSCC are more susceptible to an imbalance of antioxidant\u2010oxidative stress status.<\/jats:p>","DOI":"10.1111\/j.1600-0714.2012.01172.x","type":"journal-article","created":{"date-parts":[[2012,5,15]],"date-time":"2012-05-15T11:33:37Z","timestamp":1337081617000},"page":"736-740","source":"Crossref","is-referenced-by-count":80,"title":["Oxidative stress status and DNA damage in saliva of human subjects with oral lichen planus and oral squamous cell carcinoma"],"prefix":"10.1111","volume":"41","author":[{"given":"Farzaneh","family":"Agha\u2010Hosseini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iraj","family":"Mirzaii\u2010Dizgah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niloofar","family":"Farmanbar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Abdollahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,5,15]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/10454411980090010501"},{"key":"e_1_2_6_3_2","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1002\/ptr.2919","article-title":"Efficacy of purslane in the treatment of oral lichen planus","volume":"24","author":"Agha\u2010Hosseini F","year":"2009","journal-title":"Phytother Res"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-5037.2009.00365.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1808-8694(15)31102-2"},{"key":"e_1_2_6_6_2","first-page":"494","article-title":"Oral lichen planus: clinical presentation and management","volume":"68","author":"Edwards PC","year":"2002","journal-title":"J Can Dent Assoc"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2007.07.199"},{"key":"e_1_2_6_8_2","first-page":"37","article-title":"Immunohistochemistry analysis of P53 and Ki\u201067 proteins in oral lichen planus and normal oral mucosa","volume":"38","author":"Agha\u2010Hosseinil F","year":"2009","journal-title":"Iran J Public Health"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/biof.5520330406"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2005.07.038"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/10590500902885684"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.14.e521"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.4236\/ojst.2011.12003"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1697415"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyh058"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/jps.20874"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2006.03.016"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2005.00743.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2007.02436.x"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2010.00955.x"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0752rev"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.4103\/1477-3163.79683"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0714.2012.01172.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0714.2012.01172.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T09:30:48Z","timestamp":1698658248000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0714.2012.01172.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,15]]},"references-count":21,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["10.1111\/j.1600-0714.2012.01172.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0714.2012.01172.x","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,15]]}}}