{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:23:26Z","timestamp":1790965406005,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2012,5,29]],"date-time":"2012-05-29T00:00:00Z","timestamp":1338249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:p><jats:italic>J Oral Pathol Med<\/jats:italic> (2012) <jats:bold>41<\/jats:bold>: 728\u2013735<\/jats:p><jats:p><jats:bold>Background:\u2002<\/jats:bold> The aim of this study was to verify the validity of IL\u201021 local suppression in submandibular glands of preventing the development of Sj\u00f6gren\u2019s syndrome in non\u2010obese diabetic (NOD) mice and figure out the mechanism.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> IL\u201021 levels in submandibular glands were suppressed by ductal cannulation of IL\u201021 shRNA lentivirus. Then, saliva flow rates (SFR) and histopathologic changes of submandibular glands were measured to assess the severity of disease development. Real\u2010time PCR, flow cytometry, and immunohistochemistry were used to detect the changes of T helper cells and related cytokines.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The reduction in SFRs in NOD mice was significantly alleviated from 9 to 17\u2003weeks of age along with the suppression of IL\u201021 in submandibular glands. Lymphocytic infiltration was also milder than control NOD mice. Moreover, the lower level of IL\u201021 led to the down\u2010regulation of follicular helper T (Tfh) cells.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Local suppression of IL\u201021 in submandibular glands could retard the development of Sj\u00f6gren\u2019s syndrome in NOD mice. IL\u201021 might contribute to the development of B\u2010cell disorder in Sj\u00f6gren\u2019s syndrome via Tfh cells pathway.<\/jats:p>","DOI":"10.1111\/j.1600-0714.2012.01175.x","type":"journal-article","created":{"date-parts":[[2012,5,29]],"date-time":"2012-05-29T12:13:17Z","timestamp":1338293597000},"page":"728-735","source":"Crossref","is-referenced-by-count":20,"title":["Local suppression of IL\u201021 in submandibular glands retards the development of Sj\u00f6gren\u2019s syndrome in non\u2010obese diabetic mice"],"prefix":"10.1111","volume":"41","author":[{"given":"Hao","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoxin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangshui","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,5,29]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-007-8000-y"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2010.05.005"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2009.08.001"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.26.021607.090316"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxp112"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.06.001"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2008.02.004"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2006.01241.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7696(02)13013-0"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2009.09.009"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21945"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2010.11.007"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-031210-101400"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2009.02.002"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.22452"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0804358105"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.6.3822"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/294582"},{"key":"e_1_2_6_20_2","first-page":"124","article-title":"[Serum IL\u201021 level in patients with primary Sjogren\u2019s syndrome and clinical significance of IL\u201021]","volume":"23","author":"Yuan SL","year":"2007","journal-title":"Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00005-009-0002-4"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3083.2001.00958.x"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0300-9475.2004.01508.x"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2005.11.004"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1176676"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20091738"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.03.003"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0714.2012.01175.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0714.2012.01175.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T09:30:55Z","timestamp":1698658255000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0714.2012.01175.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,29]]},"references-count":26,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["10.1111\/j.1600-0714.2012.01175.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0714.2012.01175.x","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,29]]}}}