{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:27:56Z","timestamp":1790029676515,"version":"4.0.1"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,6,5]],"date-time":"2012-06-05T00:00:00Z","timestamp":1338854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:p>\n                    <jats:bold>Background:\u2002<\/jats:bold>\n                    Activation of innate immunity through polyinosinic:polycytidylic acid [poly(I:C)] causes acute salivary gland hypofunction. As a major consequence of poly(I:C) treatment is type I interferon (IFN) production, this study was undertaken to investigate their role in salivary gland dysfunction.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:\u2002<\/jats:bold>\n                    Different strains of mice deficient in either interferon alpha receptor (IFNAR1\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    ) or IL\u20106\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    , or IL\u201010\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    , or EBI3\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    were treated with poly(I:C). Salivary gland function was determined by measuring pilocarpine\u2010induced saliva volume. Gene expression levels were measured by real\u2010time PCR. Ca\n                    <jats:sup>2+<\/jats:sup>\n                    mobilization studies were performed using ex\u2010vivo acinar cells.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:\u2002<\/jats:bold>\n                    A single injection of poly(I:C) rapidly induced salivary gland hypofunction in wild\u2010type B6 mice (41% drop in saliva volumes compared to PBS\u2010treated mice). In contrast, the loss of function in poly(I:C)\u2010treated IFNAR\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice was only 9.6%. Gene expression analysis showed reduced levels of\n                    <jats:italic>Il\u20106, Il\u201010,<\/jats:italic>\n                    and\n                    <jats:italic>Il\u201027<\/jats:italic>\n                    in submandibular glands of poly(I:C)\u2010treated IFNAR\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice. While salivary gland dysfunction in poly(I:C)\u2010treated IL\u201010\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    and EBI3\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice was comparable to wild\u2010type mice, the IL\u20106\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice were more resistant, with only a 21% drop in function. Pilocarpine\u2010induced Ca\n                    <jats:sup>2+<\/jats:sup>\n                    flux was significantly suppressed in acinar cells obtained from poly(I:C)\u2010treated wild\u2010type mice.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:\u2002<\/jats:bold>\n                    Our data demonstrate that a combined action of type I IFNs and IL\u20106 contributes toward salivary gland hypofunction. This happens through interference with Ca\n                    <jats:sup>2+<\/jats:sup>\n                    mobilization within acinar cells. Thus, in acute viral infections and diseases like Sj\u00f6gren\u2019s syndrome, elevated levels of type I IFNs and IL\u20106 can directly affect glandular function.\n                  <\/jats:p>","DOI":"10.1111\/j.1600-0714.2012.01181.x","type":"journal-article","created":{"date-parts":[[2012,6,5]],"date-time":"2012-06-05T11:49:10Z","timestamp":1338896950000},"page":"66-72","source":"Crossref","is-referenced-by-count":44,"title":["Salivary gland hypofunction induced by activation of innate immunity is dependent on type I interferon signaling"],"prefix":"10.1111","volume":"42","author":[{"given":"Seshagiri\u2010Rao","family":"Nandula","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paromita","family":"Dey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn L.","family":"Corbin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig S.","family":"Nunemaker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harini","family":"Bagavant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umesh S.","family":"Deshmukh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,6,5]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.2010.01229.x"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1999.tb02045.x"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.30381"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.30295"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/407031"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2010.080036"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2008.00700.x"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2010.06.012"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.3109\/08916930903510872"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0510837103"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncprheum0173"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200738013"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2010.118"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8009221"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.110.174946"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.4161\/isl.3.1.14133"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-0773"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00022-07"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.11.6876"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0902005"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.6.12.4770"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.67.041703.084745"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2009.01600.x"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.10.6723"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.9.6176"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.11.6770"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00144.2008"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.27362"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kel067"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep100"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2011.12.005"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.22.13490"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2010.11.004"}],"container-title":["Journal of Oral Pathology &amp; 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