{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:45:36Z","timestamp":1792100736755,"version":"4.4.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,8,24]],"date-time":"2012-08-24T00:00:00Z","timestamp":1345766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Recurrent aphthous ulcerations (<jats:styled-content style=\"fixed-case\">RAU<\/jats:styled-content>), or recurrent aphthous stomatitis, is recognized as one of the most common oral mucosal diseases worldwide. It was noted some connection between immunity to cow's milk proteins (<jats:styled-content style=\"fixed-case\">CMP<\/jats:styled-content>) and oral diseases.<\/jats:p><jats:p>The goal of this study was to determine the prevalence of the increased levels of serum antibodies to specific cow's milk proteins (<jats:styled-content style=\"fixed-case\">SCMP<\/jats:styled-content>), constituents of cheese or of whey, by enzyme\u2010linked immunosorbent assay (<jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>) test, in subjects who have <jats:styled-content style=\"fixed-case\">RAU<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty subjects with <jats:styled-content style=\"fixed-case\">RAU<\/jats:styled-content> and 50 healthy people, as controls (<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>), were included in this research. Levels of serum <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content> antibodies to <jats:styled-content style=\"fixed-case\">SCMP<\/jats:styled-content> were determined by <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>. The statistical analysis of data was performed by <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>ilcoxon rank sum test with continuity correction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The levels of serum anti\u2010<jats:styled-content style=\"fixed-case\">SCMP I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content> antibodies were significantly higher in subjects with <jats:styled-content style=\"fixed-case\">RAU<\/jats:styled-content> in comparison with controls (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.005).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results indicate the strong association between high levels of serum anti\u2010<jats:styled-content style=\"fixed-case\">SCMP I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content> antibodies, especially to caseins: \u03b1\u2010, \u03b2\u2010, and \u03ba\u2010casein from cow's milk and clinical manifestations of <jats:styled-content style=\"fixed-case\">RAU<\/jats:styled-content>. Serum immunity to the whey proteins in subjects with <jats:styled-content style=\"fixed-case\">RAU<\/jats:styled-content> was not in so high percentage expressed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1600-0714.2012.01204.x","type":"journal-article","created":{"date-parts":[[2012,8,24]],"date-time":"2012-08-24T12:03:12Z","timestamp":1345809792000},"page":"82-88","source":"Crossref","is-referenced-by-count":9,"title":["The role of specific cow's milk proteins in the etiology of recurrent aphthous ulcers"],"prefix":"10.1111","volume":"42","author":[{"given":"Irina","family":"Besu","sequence":"first","affiliation":[{"name":"Institute of Oncology and Radiology of Serbia Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ljiljana","family":"Jankovic","sequence":"additional","affiliation":[{"name":"Clinic for Periodontology and Oral medicine Faculty of Stomatology University of Belgrade Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Konic\u2010Ristic","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Metabolism Institute for Medical Research Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanvila","family":"Raskovic","sequence":"additional","affiliation":[{"name":"Institute of Allergology and Immunology Clinical Center of Serbia School of Medicine University of Belgrade Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeri","family":"Besu","sequence":"additional","affiliation":[{"name":"Dental Ordination Dr Besu Zrenjanin Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milanko","family":"Djuric","sequence":"additional","affiliation":[{"name":"Clinic for Dentistry School of Medicine University of Novi Sad Novi Sad Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasa","family":"Cakic","sequence":"additional","affiliation":[{"name":"Clinic for Periodontology and Oral medicine Faculty of Stomatology University of Belgrade Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ileana Ursu","family":"Magdu","sequence":"additional","affiliation":[{"name":"Clinic for Periodontology and Oral medicine Faculty of Stomatology University of Belgrade Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zorica","family":"Juranic","sequence":"additional","affiliation":[{"name":"Institute of Oncology and Radiology of Serbia Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,8,24]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"95","article-title":"Recurrent aphthous stomatitis","volume":"31","author":"Ship JA","year":"2000","journal-title":"Quintessence Int"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1991.tb00950.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(64)80046-9"},{"key":"e_1_2_5_5_1","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1136\/jcp.26.5.371","article-title":"Food antibodies in oral disease: a study of serum antibodies to food proteins in aphthous ulceration and other oral diseases","volume":"26","author":"Thomas HC","year":"1973","journal-title":"J Clin Pathol"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2009.01595.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.1999.00563.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.080192"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02169-3"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)81401-5"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1995.tb01113.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1996.tb04639.x"},{"key":"e_1_2_5_13_1","first-page":"572","article-title":"Milk allergy. 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