{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:09:42Z","timestamp":1790842182677,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,5,24]],"date-time":"2004-05-24T00:00:00Z","timestamp":1085356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J Oral Sciences"],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:p>In the present study, multivariate analyses were performed on clinical and treatment variables that may influence the outcome of endodontic treatment. Data collected in a previous clinical\u2010radiographic follow\u2010up study were used. Of 810 treated, 675 roots in 498 teeth were followed for 6\u2003months to 4\u2003yr. Of these, 192 (the CAP group) had pre\u2010existing, chronic apical periodontitis and 483 (the NAP group) had not. Root canal treatment followed a standard procedure with one of three sealers chosen at random. Demographic, clinical and radiographic variables were recorded at the start of, and during treatment. The periapical index (PAI) score was used to record the outcome of treatment, and applied in two different endpoint modes (END1 and END2) as the dependent variable for multivariate statistical analyses using logistic regression and the general model. The modes reflected increasing PAI scores (END1) and conventional success\/failure assessment (END2). Dropouts were largely similar to the cases followed up. A total of 10 preoperative and peroperative variables were found to be significantly associated with treatment outcome by the multivariate analyses of either the total material or the NAP or CAP subgroups. Several of these were not significant in univariate analyses (e.g. the effect of sealer). Conventional success\/failure analyses (END2) identified fewer of the influential variables and had low explanatory power, whereas PAI scores on an ordinal scale (END1) were most sensitive in identifying variables of influence on the treatment outcome.<\/jats:p>","DOI":"10.1111\/j.1600-0722.2004.00122.x","type":"journal-article","created":{"date-parts":[[2004,5,24]],"date-time":"2004-05-24T07:25:36Z","timestamp":1085383536000},"page":"224-230","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":152,"title":["A multivariate analysis of the outcome of endodontic treatment"],"prefix":"10.1111","volume":"112","author":[{"given":"Dag","family":"\u00d8rstavik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vibeke","family":"Qvist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaj","family":"Stoltze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,5,24]]},"reference":[{"key":"e_1_2_20_2_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-1546.2002.20105.x"},{"key":"e_1_2_20_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/00220345820610010401"},{"key":"e_1_2_20_4_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016358909007710"},{"key":"e_1_2_20_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(80)80186-5"},{"key":"e_1_2_20_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.1987.tb00621.x"},{"key":"e_1_2_20_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(79)80154-5"},{"key":"e_1_2_20_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.1986.tb00119.x"},{"key":"e_1_2_20_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.1987.tb00629.x"},{"key":"e_1_2_20_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.1996.tb01361.x"},{"key":"e_1_2_20_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780131106"},{"key":"e_1_2_20_12_2","first-page":"347","article-title":"Micro\u2010organisms from necrotic pulp of traumatized teeth","volume":"25","author":"Bergenholtz G.","year":"1974","journal-title":"Odontol Revy"},{"key":"e_1_2_20_13_2","volume-title":"Ume\u00e5 University Odontological Dissertations no. 7","author":"Sundqvist G.","year":"1976"},{"key":"e_1_2_20_14_2","first-page":"475","article-title":"Influence on periapical tissues of indigenous oral bacteria and necrotic pulp tissue in monkeys","volume":"89","author":"M\u00f6ller \u00c5JR","year":"1981","journal-title":"Scand J Dent Res"},{"key":"e_1_2_20_15_2","first-page":"106","volume-title":"Essential endodontology.","author":"Dahl\u00e9n G","year":"1998"},{"issue":"21","key":"e_1_2_20_16_2","first-page":"1","article-title":"The dependence of the results of pulp therapy on certain factors","volume":"14","author":"Strindberg L.","year":"1956","journal-title":"Acta Odont Scand"},{"key":"e_1_2_20_17_2","first-page":"257","article-title":"Correlation of positive cultures with the prognosis for root canal treatment","volume":"15","author":"Engstr\u00f6m B.","year":"1964","journal-title":"Odontol Revy"},{"key":"e_1_2_20_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2591.1997.00092.x"},{"key":"e_1_2_20_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1995.tb00254.x"},{"key":"e_1_2_20_20_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1998.69.2.158"},{"key":"e_1_2_20_21_2","first-page":"3","article-title":"A histological and roentgenological study of the periapical region of human upper incisors","volume":"18","author":"Brynolf I.","year":"1967","journal-title":"Odontol Revy"},{"key":"e_1_2_20_22_2","first-page":"146","article-title":"The prognosis of pulp and root canal therapy. 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