{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:10:42Z","timestamp":1792627842254,"version":"4.5.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,7,26]],"date-time":"2004-07-26T00:00:00Z","timestamp":1090800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J Oral Sciences"],"published-print":{"date-parts":[[2004,8]]},"abstract":"<jats:p>Nitric oxide (NO) is a biological effector molecule involved in a large variety of reactions and, as synthesized by inducible nitric oxide synthase (iNOS), has many important roles in inflammatory conditions. This study aimed to evaluate the anti\u2010inflammatory effects of an iNOS\u2010specific inhibitor, <jats:italic>N<\/jats:italic>\u2010(3\u2010(aminomethyl)benzyl)acetamidine (1400W), on experimentally induced rat pulpitis in the upper incisors of 6\u2010wk\u2010old male Wistar rats. 1400W (1\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>), the non\u2010specific NOS inhibitor <jats:italic>N<\/jats:italic><jats:sup>G<\/jats:sup>\u2010nitro\u2010<jats:sc>l<\/jats:sc>\u2010arginine methyl ester (<jats:sc>l<\/jats:sc>\u2010NAME, 50\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>), or sterile saline (control) were administered before the application of lipopolysaccharide (LPS). Rats were killed 3, 6, 9, 12, 24, 48, and 72 h after LPS application, and immunocompetent cells were detected immunohistochemically. The numbers of granulocytes infiltrating into the pulp were significantly depressed in the 1400W group compared with the saline and <jats:sc>l<\/jats:sc>\u2010NAME groups. The kinetics of the macrophages and Ia<jats:sup>+<\/jats:sup> cells in the 1400W group were similar to those in the <jats:sc>l<\/jats:sc>\u2010NAME group, while the maximum numbers in both groups were significantly reduced compared with those in the saline group. These results suggest that NO may be responsible for the infiltration of immunocompetent cells in the progress of pulpitis, and that 1400W is a promising candidate for controlling pulpal inflammatory reactions.<\/jats:p>","DOI":"10.1111\/j.1600-0722.2004.00139.x","type":"journal-article","created":{"date-parts":[[2004,7,26]],"date-time":"2004-07-26T15:44:12Z","timestamp":1090856652000},"page":"332-337","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Effects of an inducible nitric oxide synthase inhibitor on experimentally induced rat pulpitis"],"prefix":"10.1111","volume":"112","author":[{"given":"Hiromi 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