{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:47:36Z","timestamp":1761058056655},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,9,29]],"date-time":"2004-09-29T00:00:00Z","timestamp":1096416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J Oral Sciences"],"published-print":{"date-parts":[[2004,10]]},"abstract":"<jats:p>Tooth eruption requires alveolar bone resorption and formation, both of which appear to be regulated by the dental follicle. Osteoclastogenesis needed for this bone resorption appears to occur as a result of a reduction in the expression of the osteoprotegerin (<jats:italic>OPG<\/jats:italic>) gene in the dental follicle at a specific time. This reduction in expression is mediated<jats:italic>in vitro<\/jats:italic>in the follicle cells by colony\u2010stimulating factor\u20101 (CSF\u20101) and parathyroid hormone\u2010related protein (PTHrP). Using enzyme\u2010linked immunosorbent assays and immunoblotting, this study shows that the reduction in expression of<jats:italic>OPG<\/jats:italic>after incubation of the dental follicle cells in either CSF\u20101 or PTHrP also results in a reduction in its secretion. We also show, by laser capture microdissection, that PTHrP is expressed<jats:italic>in vivo<\/jats:italic>in the stellate reticulum such that it could inhibit<jats:italic>OPG<\/jats:italic>expression via a paracrine effect on the follicle. Bone formation is enhanced by OPG secretion, and incubation of the follicle cells with bone morphogenetic protein\u20102 (BMP\u20102) enhances OPG secretion. Thus, a reduction in secretion of the OPG protein at defined times may promote the osteoclastogenesis and alveolar bone resorption needed for eruption, and enhancement of OPG secretion at other times may promote alveolar bone formation.<\/jats:p>","DOI":"10.1111\/j.1600-0722.2004.00156.x","type":"journal-article","created":{"date-parts":[[2004,9,29]],"date-time":"2004-09-29T13:59:53Z","timestamp":1096466393000},"page":"439-444","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Regulation of secretion of osteoprotegerin in rat dental follicle cells"],"prefix":"10.1111","volume":"112","author":[{"given":"G. 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