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These are among the most common statistical pitfalls in oral health research when exploring the relationship between clinical variables using multiple regression analysis. We hope that this article will show why these problems arise and how they can be avoided and overcome. Examples from the periodontal literature will be used to illustrate how collinearity and multicollinearity can seriously distort the model development process as a result of the phenomenon of mathematical coupling. Knowledge of these problems can help to eliminate misleading results and improve any subsequent interpretations. Regression analyses are useful tools in oral health research when their limitations are recognized. However, care is required in planning and it is worthwhile seeking statistical advice when formulating the study's research questions.<\/jats:p>","DOI":"10.1111\/j.1600-0722.2004.00160.x","type":"journal-article","created":{"date-parts":[[2004,9,29]],"date-time":"2004-09-29T13:59:53Z","timestamp":1096466393000},"page":"389-397","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Collinearity in linear regression is a serious problem in oral health research"],"prefix":"10.1111","volume":"112","author":[{"given":"Yu\u2010Kang","family":"Tu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Clerehugh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark S.","family":"Gilthorpe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,9,29]]},"reference":[{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-3242-6"},{"key":"e_1_2_13_3_2","first-page":"236","article-title":"The application of multilevel, multivariate modelling to orthodontic research data","volume":"17","author":"Gilthorpe MS","year":"2000","journal-title":"Community Dent Health"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(62)90116-9"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780010109"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780101206"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/154405910208101013"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2003.10.001"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2003.09.004"},{"key":"e_1_2_13_10_2","first-page":"185","volume-title":"Primer of applied regression and analysis of variance","author":"Glantz SA","year":"2001"},{"key":"e_1_2_13_11_2","first-page":"294","volume-title":"Multiple regression in behavioral research","author":"Pedhazur EJ","year":"1997"},{"key":"e_1_2_13_12_2","first-page":"134","volume-title":"Regression with graphics. 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