{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:20:33Z","timestamp":1762100433666},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,10,3]],"date-time":"2005-10-03T00:00:00Z","timestamp":1128297600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J Oral Sciences"],"published-print":{"date-parts":[[2005,10]]},"abstract":"<jats:p>Tooth eruption in the rat requires bone resorption resulting from a major burst of osteoclastogenesis on postnatal day 3 and a minor burst of osteoclastogenesis on postnatal day 10 in the alveolar bone of the first mandibular molar. The dental follicle regulates the major burst on postnatal day 3 by down\u2010regulating its osteoprotegerin (OPG) gene expression to enable osteoclastogenesis to occur. To determine the role of receptor activator of nuclear factor\u2010kappa B ligand (RANKL) in tooth eruption, its gene expression was measured on postnatal days 1\u201311 in the dental follicle. The results show that RANKL expression was significantly elevated on postnatal days 9\u201311 in comparison to low expression levels at earlier time\u2010points. As OPG expression is high at this latter time\u2010point, this increase in RANKL expression would be needed for stimulating the minor burst of osteoclastogenesis. Tumor necrosis factor\u2010<jats:italic>\u03b1<\/jats:italic>enhances RANKL gene expression<jats:italic>in vitro<\/jats:italic>and it may be responsible for up\u2010regulating RANKL<jats:italic>in vivo<\/jats:italic>. Transforming growth factor\u2010<jats:italic>\u03b2<\/jats:italic>1 and interleukin\u20101<jats:italic>\u03b1<\/jats:italic>also enhance RANKL gene expression<jats:italic>in vitro<\/jats:italic>but probably have no effect<jats:italic>in vivo<\/jats:italic>because they are maximally expressed early. Bone morphogenetic protein\u20102 acts to down\u2010regulate RANKL expression<jats:italic>in vitro<\/jats:italic>and,<jats:italic>in vivo<\/jats:italic>, may promote alveolar bone growth in the basal region of the tooth.<\/jats:p>","DOI":"10.1111\/j.1600-0722.2005.00245.x","type":"journal-article","created":{"date-parts":[[2005,10,3]],"date-time":"2005-10-03T11:03:05Z","timestamp":1128337385000},"page":"404-409","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Chronology and regulation of gene expression of RANKL in the rat dental follicle"],"prefix":"10.1111","volume":"113","author":[{"given":"D.","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. 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