{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:49:32Z","timestamp":1763945372389},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,11,28]],"date-time":"2005-11-28T00:00:00Z","timestamp":1133136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J Oral Sciences"],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:p>Human dental plaque is thought to contribute to disease, not only in the oral cavity but also at other body sites. To investigate the pathogenicity of dental plaque in tissues remote from the mouth, we examined the ability of human supragingival dental plaque to induce infective endocarditis (IE) in rats. In total, 15 out of 27 catheterized rats survived after intravenous injections with human supragingival dental plaque suspensions containing 3\u2003\u00d7\u200310<jats:sup>6<\/jats:sup> colony\u2010forming units (CFU) of bacterial cells. In surviving rats, infected vegetations were formed in all except one rat. The microbial composition of the infected vegetations was different from that of the respective dental plaque inocula, with <jats:italic>Streptococcus\u2003oralis<\/jats:italic> comprising the majority of the isolates. In rats affected with endocarditis, the aortic sinus was filled with fibrinous vegetation containing bacteria. Inflammatory cells infiltrated the aortic valve, the aorta adjacent to the valve, and the cardiac muscles. The inoculation of catheterized rats with a cell suspension of <jats:italic>S.\u2003oralis<\/jats:italic> isolate (5\u2003\u00d7\u200310<jats:sup>6<\/jats:sup> CFU) was not lethal but capable of inducing endocarditis in all animals. The results suggest that if dental plaque were introduced into the bloodstream, it could serve as a potent source of bacteria causing IE in humans.<\/jats:p>","DOI":"10.1111\/j.1600-0722.2005.00258.x","type":"journal-article","created":{"date-parts":[[2005,11,28]],"date-time":"2005-11-28T10:54:00Z","timestamp":1133175240000},"page":"499-504","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Experimental infective endocarditis induced by human supragingival dental plaque in rats"],"prefix":"10.1111","volume":"113","author":[{"given":"Emi","family":"Nagata","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidehito","family":"Okayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiro\u2010O","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ichiro","family":"Semba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masakazu","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiko","family":"Oho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,28]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/milmed\/166.1.85"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0011-8532(03)00023-5"},{"key":"e_1_2_6_4_2","first-page":"107","article-title":"Oral diseases and conditions throughout the lifespan. II. Systemic diseases","volume":"52","author":"Beltran\u2010Aguilar ED","year":"2004","journal-title":"Gen Dent"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200207000-00018"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1198-743X.2004.00776.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.10.1554"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2005.01440.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.156.5.97-03006"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.5.2513-2515.2005"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0272.1993.tb02700.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.33.5.1399-1401.1995"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.3.1405-1407.2005"},{"key":"e_1_2_6_14_2","first-page":"2.50.1","volume-title":"Infectious diseases","author":"Moreillon P","year":"1999"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1080\/0036554021000026993"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.67.585"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002469900477"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1977.tb01888.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.2.210"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.1997.tb01069.x"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2000.tb01438.x"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.60.11.4809-4818.1992"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.65.3.994-1002.1997"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.1.86-92.2004"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2003.12.001"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.8.4759-4766.2003"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(73)90057-5"},{"key":"e_1_2_6_28_2","first-page":"630","volume-title":"Histopathologic Technic and Practical Histochemistry","author":"Lillie RD","year":"1976"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(66)90028-8"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.1994.tb00214.x"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.2005.tb03742.x"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.67.901"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-129-10-199811150-00002"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1099\/00222615-39-3-179"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5520(02)00005-3"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1099\/00222615-41-1-10"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.1999.tb02395.x"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(03)01454-1"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.183.12.3770-3783.2001"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.2.558-563.2003"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302x.2004.00168.x"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.9.4438-4441.2003"}],"container-title":["European Journal of Oral Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0722.2005.00258.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0722.2005.00258.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T01:29:36Z","timestamp":1697074176000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0722.2005.00258.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11,28]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["10.1111\/j.1600-0722.2005.00258.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0722.2005.00258.x","archive":["Portico"],"relation":{},"ISSN":["0909-8836","1600-0722"],"issn-type":[{"value":"0909-8836","type":"print"},{"value":"1600-0722","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,11,28]]},"assertion":[{"value":"2005-11-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}