{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T10:07:31Z","timestamp":1791022051658,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,2,6]],"date-time":"2006-02-06T00:00:00Z","timestamp":1139184000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J Oral Sciences"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:p>The aim of this study was to determine the effect of interleukin\u201010 (IL\u201010) on the gene expression of osteoclastogenic regulatory molecules in rat dental follicle cells. Interleukin\u201010 is an anti\u2010inflammatory cytokine that inhibits alveolar bone resorption, but the molecular basis for this is unknown. Alveolar bone resorption is required for tooth eruption and the dental follicle functions to regulate the osteoclastogenesis needed for eruption. It does this by regulating its expression of receptor activator of nuclear factor\u2010kappa B ligand (RANKL), colony\u2010stimulating factor\u20101 (CSF\u20101), and osteoprotegerin (OPG). In this study, dental follicle cells were treated with IL\u201010, and the effect on gene expression of CSF\u20101, RANKL, and OPG was measured by reverse transcription\u2013polymerase chain reaction (RT\u2013PCR). Interleukin\u201010 enhanced the expression of OPG and down\u2010regulated the expression of RANKL and CSF\u20101. Laser capture microdissection was carried out to detect IL\u201010 gene expression in the dental follicle. Knockdown of the IL\u201010 gene expression in the follicle cells was accomplished using a short interfering RNA (siRNA) targeting IL\u201010 mRNA. In these knockdowns, RANKL expression was increased and OPG expression was decreased. All of these results suggest that IL\u201010 inhibits bone resorption by up\u2010regulating OPG expression while down\u2010regulating expression of RANKL and CSF\u20101.<\/jats:p>","DOI":"10.1111\/j.1600-0722.2006.00283.x","type":"journal-article","created":{"date-parts":[[2006,2,6]],"date-time":"2006-02-06T13:48:17Z","timestamp":1139233697000},"page":"42-49","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":93,"title":["Effect of interleukin\u201010 on gene expression of osteoclastogenic regulatory molecules in the rat dental follicle"],"prefix":"10.1111","volume":"114","author":[{"given":"Dawen","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaomian","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary E.","family":"Wise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,2,6]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/154411130201300403"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001680303"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1985.tb00461.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/00220345890680021001"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.7.3597"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81569-X"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.163.1.434"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80209-3"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo.139.3.5837"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/00220345950740090801"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/00220345000790120301"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9969(01)00109-1"},{"key":"e_1_2_6_14_2","first-page":"429","volume-title":"The biological mechanisms of tooth eruption, resorption and replacement by implants","author":"Cielinski MJ","year":"1994"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1999.14.9.1486"},{"key":"e_1_2_6_16_2","first-page":"17","article-title":"Expression of RANKL and OPG mRNA in periodontal disease: possible involvement in bone destruction","volume":"11","author":"Liu D","year":"2003","journal-title":"Int J Mol Med"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2003.00615.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/154405910408300216"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9969(02)00153-X"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1991.62.8.504"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.3.391"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2003.01395.x"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2001.028003233.x"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2161559"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.4.1172"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2008.00711.x"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.117.4.1162"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9969(99)00120-X"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041650321"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.157.2.936"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2000.15.5.911"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.7.3626"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1177\/154405910308200812"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2001.01448.x"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00319370"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2004.01.009"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.7.4858"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI11176"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008198200"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2004.00760.x"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1177\/00220345010800030801"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2002.01603.x"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0722.2003.00051.x"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9969(03)00201-2"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1080\/03008200390181753"}],"container-title":["European Journal of Oral Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0722.2006.00283.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0722.2006.00283.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T01:21:59Z","timestamp":1696987319000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0722.2006.00283.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,2]]}},"alternative-id":["10.1111\/j.1600-0722.2006.00283.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0722.2006.00283.x","archive":["Portico"],"relation":{},"ISSN":["0909-8836","1600-0722"],"issn-type":[{"value":"0909-8836","type":"print"},{"value":"1600-0722","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,2]]},"assertion":[{"value":"2006-02-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}