{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T18:46:56Z","timestamp":1791139616770,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"s1","license":[{"start":{"date-parts":[[2006,5,2]],"date-time":"2006-05-02T00:00:00Z","timestamp":1146528000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J Oral Sciences"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:p>Mutations in both the human <jats:italic>amelogenin<\/jats:italic> and human matrix <jats:italic>metalloproteinase\u201020<\/jats:italic> (<jats:italic>MMP20<\/jats:italic>, enamelysin) genes cause <jats:italic>amelogenesis imperfecta<\/jats:italic>. Both genes have also been individually deleted from the mouse and each deletion results in defective dental enamel. Here, we compare the stage\u2010specific progression of enamel development in continuously erupting mouse incisors from amelogenin null and MMP\u201020 null mice. Our goal was to closely examine differences in enamel and enamel organ structure between these mice that would allow a better understanding of each protein's function. The predominant feature of the amelogenin null incisors was the late onset of mineral deposition, with little or no protein present within the forming mineral. Conversely, the developing MMP\u201020 null incisors had a layer of protein between the apical surface of the ameloblasts and the forming enamel. Furthermore, the protein present within the enamel matrix was disorganized. An analysis of crystal structure demonstrated that the thin amelogenin null enamel was plate\u2010like, while the MMP\u201020 null enamel had a disrupted prism pattern. These results suggest that amelogenin is essential for appositional crystal growth during the early to mid\u2010secretory stage and for the maintenance of the crystal ribbon structure. They also suggest that MMP\u201020 is responsible for enamel matrix organization and for subsequent efficient reabsorption of enamel matrix proteins. Both genes are essential for the generation of full\u2010thickness enamel containing the characteristic decussating prism pattern.<\/jats:p>","DOI":"10.1111\/j.1600-0722.2006.00292.x","type":"journal-article","created":{"date-parts":[[2006,5,4]],"date-time":"2006-05-04T15:27:15Z","timestamp":1146756435000},"page":"18-23","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["A developmental comparison of matrix metalloproteinase\u201020 and amelogenin null mouse enamel"],"prefix":"10.1111","volume":"114","author":[{"given":"John D.","family":"Bartlett","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziedonis","family":"Skobe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel H.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Timothy","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok B.","family":"Kulkarni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn W.","family":"Gibson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,5,2]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-7236-1751-8.50008-9"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/10454411990100040101"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/10454411980090020101"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/00220345410200020201"},{"key":"e_1_2_6_6_2","first-page":"233","article-title":"Moisture, inorganic and organic contents of enamel and dentin from carious teeth","volume":"25","author":"Lefevre M","year":"1938","journal-title":"JADA"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000261131"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/154405910408300505"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/03008200390152124"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.1380050310"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9969(96)00099-4"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9969(02)00003-1"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2004.024505"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M104624200"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M209100200"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/154405910408301204"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0722.2002.21301.x"}],"container-title":["European Journal of Oral Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0722.2006.00292.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0722.2006.00292.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T06:43:42Z","timestamp":1695797022000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0722.2006.00292.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5]]},"references-count":16,"journal-issue":{"issue":"s1","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["10.1111\/j.1600-0722.2006.00292.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0722.2006.00292.x","archive":["Portico"],"relation":{},"ISSN":["0909-8836","1600-0722"],"issn-type":[{"value":"0909-8836","type":"print"},{"value":"1600-0722","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,5]]},"assertion":[{"value":"2006-05-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}