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Ovariectomized female BALB\/c mice were treated with placebo\u2010 or testosterone\u2010containing hormone pellets for 14 d. Glands were collected and total RNA was isolated. Samples were analyzed for differential expression of mRNA using CodeLink microarrays, and the data were evaluated using <jats:sc>genesifter<\/jats:sc>. Testosterone significantly influenced the expression of over 500 genes, and while many (<jats:italic>n<\/jats:italic>\u2003=\u2003214) of the genes were similarly differentially expressed in androgen\u2010treated males, there were also many that were unique. These findings support our hypotheses that testosterone extensively influences gene expression in the female submandibular gland, and that the nature of this influence is variable between sexes.<\/jats:p>","DOI":"10.1111\/j.1600-0722.2006.00360.x","type":"journal-article","created":{"date-parts":[[2010,9,15]],"date-time":"2010-09-15T09:54:13Z","timestamp":1284544453000},"page":"328-336","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Influence of testosterone on gene expression in the ovariectomized mouse submandibular gland"],"prefix":"10.1111","volume":"114","author":[{"given":"Nathaniel S.","family":"Treister","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen 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