{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T20:34:45Z","timestamp":1780346085093,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,25]],"date-time":"2006-07-25T00:00:00Z","timestamp":1153785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J Oral Sciences"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:p>Microorganisms remaining beneath restorations can cause secondary caries and pulp damage. Because of this, antimicrobial treatment could be useful. The aim of this study was to evaluate the antibacterial effect of the HealOzone device on <jats:italic>Streptococcus\u2003mutans<\/jats:italic> and to compare it with the already proven activity of two dentin\u2010bonding systems. Thirty\u2010five human molars were divided into 5 groups. Cavities were then cut into the teeth (<jats:italic>n<\/jats:italic>\u2003=\u200328 cavities per group). After sterilization, the teeth were left in broth cultures of 10<jats:sup>6<\/jats:sup> colony\u2010forming units (CFU) ml<jats:sup>\u22121<\/jats:sup> of <jats:italic>S.\u2003mutans<\/jats:italic> at 36\u00b0C for 48\u2003h. The appropriate treatment followed (group A, control; group B, Clearfil SE Bond; group C, Clearfil Protect Bond; group D, 40\u2003s of treatment with ozone; and group E, 80\u2003s of treatment with ozone), and the cavities were then filled with composite resin. After 72\u2003h, the restorations were removed, dentin chips were collected with an excavator, and the total number of microorganisms was determined. All treatments significantly reduced the number of <jats:italic>S.\u2003mutans<\/jats:italic> present compared with the control group. The antimicrobial effect of both bonding systems and treatment with 80\u2003s of ozone was significantly higher than the 40\u2003s ozone treatment. In conclusion, HealOzone and the bonding systems show striking antimicrobial effects against <jats:italic>S.\u2003mutans.<\/jats:italic><\/jats:p>","DOI":"10.1111\/j.1600-0722.2006.00363.x","type":"journal-article","created":{"date-parts":[[2010,9,15]],"date-time":"2010-09-15T09:54:10Z","timestamp":1284544450000},"page":"349-353","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Antibacterial effect of an ozone device and its comparison with two dentin\u2010bonding systems"],"prefix":"10.1111","volume":"114","author":[{"given":"Olga","family":"Polydorou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Pelz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Hahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,25]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1993.0134"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(86)80202-3"},{"key":"e_1_2_6_4_2","first-page":"335","article-title":"The protective effect of a liner applied as a thin film beneath deep composite resin fillings. A histologic investigation","volume":"24","author":"Brannstrom M","year":"1973","journal-title":"Odontol Rev"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-5712(97)00013-4"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2005.05.009"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/00220345940730100901"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/00220345940730080701"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4636(19980315)39:4<511::AID-JBM1>3.0.CO;2-M"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2842.2001.00659.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/00220345970760030901"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.26.3.391-393.1973"},{"key":"e_1_2_6_13_2","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1128\/am.29.3.340-344.1975","article-title":"Inactivation of viruses and bacteria by ozone, with and without sonication","volume":"29","author":"Busleson GR","year":"1975","journal-title":"Appl Microbiol"},{"key":"e_1_2_6_14_2","doi-asserted-by":"crossref","first-page":"3471","DOI":"10.1128\/aem.61.9.3471-3475.1995","article-title":"Efficacy of ozonated water against various food\u2010related microorganisms","volume":"61","author":"Restaino L","year":"1995","journal-title":"Appl Environ Microbiol"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1159\/000016630"},{"key":"e_1_2_6_16_2","first-page":"121","article-title":"Studies on the biological effects of ozone: 3. An attempt to define conditions for optimal induction of cytokines","volume":"12","author":"Bocci V","year":"1993","journal-title":"Lymphokine Cytokine Res"},{"key":"e_1_2_6_17_2","first-page":"59","article-title":"Microbicidal effects of ozone solution on methicillin\u2010resistant Staphylococcus aureus","volume":"19","author":"Yamayoshi T","year":"1993","journal-title":"Drugs Exp Clin Res"},{"key":"e_1_2_6_18_2","first-page":"56","article-title":"Effect of ozone on the oral microbiota and clinical severity of primary root caries","volume":"17","author":"Baysan A","year":"2004","journal-title":"Am J Dent"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004770-200411000-00007"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0109-5641(93)90053-S"},{"key":"e_1_2_6_21_2","first-page":"257","article-title":"Antibacterial activity of dentin bonding systems, resin\u2010modified glass ionomers, and polyacid\u2010modified composite resins","volume":"21","author":"Meiers JC","year":"1996","journal-title":"Oper Dent"},{"key":"e_1_2_6_22_2","first-page":"106","article-title":"Antibacterial activity of proprietary self\u2010etching primers","volume":"11","author":"Imazato S","year":"1998","journal-title":"Am J Dent"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0722.2002.11221.x"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-5712(03)00006-X"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1177\/154405910508400116"},{"key":"e_1_2_6_26_2","first-page":"149","volume-title":"Collins' and Lyne's microbiological methods","author":"Collins CH","year":"1995"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0300-5712(95)93576-N"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2842.2004.01332.x"},{"key":"e_1_2_6_29_2","first-page":"151","article-title":"A clinical, microbiologic, and radiographic study of deep caries lesions after incomplete caries removal","volume":"33","author":"Maltz M","year":"2002","journal-title":"Quintessence Int"}],"container-title":["European Journal of Oral Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0722.2006.00363.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0722.2006.00363.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T02:41:03Z","timestamp":1696992063000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0722.2006.00363.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7,25]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["10.1111\/j.1600-0722.2006.00363.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0722.2006.00363.x","archive":["Portico"],"relation":{},"ISSN":["0909-8836","1600-0722"],"issn-type":[{"value":"0909-8836","type":"print"},{"value":"1600-0722","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7,25]]},"assertion":[{"value":"2006-07-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}